Toward Polymeric Room Temperature Acid Generators

IF 2.5 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Joel W. Roberts, Amie N. Lanzendorf, Jazmin E. Aguilar-Romero, Mara L. Paterson, Catherine A. Jalomo, Ephraim G. Morado, Steven C. Zimmerman
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引用次数: 0

Abstract

Although a variety of acid-generating molecules have been developed, the formation of toxic byproducts and the need for light-activation or temperatures that may be incompatible with physiological conditions leave room for the optimization of biocompatible acid-generators. Herein, we report 4-hydroxybenzyl chloride derivatives that generate hydrochloric acid via hydrolysis at the benzylic position at room temperature in the absence of light. Utilizing the acetal protected 4-hydroxybenzyl chloride scaffold, we access a myriad of compounds that generate acid at different rates.

Abstract Image

开发聚合物室温酸发生器。
虽然已经开发出了多种酸生成分子,但由于会形成有毒副产物,而且需要光激活或与生理条件不相容的温度,因此生物相容性酸生成器还有待优化。在此,我们报告了 4-羟基苄基氯衍生物,它能在室温无光条件下通过苄基位置的水解生成盐酸。利用受缩醛保护的 4-羟基苄基氯支架,我们获得了以不同速率生成酸的大量化合物。
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来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
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