The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-10-31 DOI:10.3390/biom14111387

Avisek Majumder, Shabana Bano, Kasturi Bala Nayak

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Abstract

One-carbon (1C) metabolism is a complex network of metabolic reactions closely related to producing 1C units (as methyl groups) and utilizing them for different anabolic processes, including nucleotide synthesis, methylation, protein synthesis, and reductive metabolism. These pathways support the high proliferative rate of cancer cells. While drugs that target 1C metabolism (like methotrexate) have been used for cancer treatment, they often have significant side effects. Therefore, developing new drugs with minimal side effects is necessary for effective cancer treatment. Methionine, glycine, and serine are the main three precursors of 1C metabolism. One-carbon metabolism is vital not only for proliferative cells but also for non-proliferative cells in regulating energy homeostasis and the aging process. Understanding the potential role of 1C metabolism in aging is crucial for advancing our knowledge of neoplastic progression. This review provides a comprehensive understanding of the molecular complexities of 1C metabolism in the context of cancer and aging, paving the way for researchers to explore new avenues for developing advanced therapeutic interventions for cancer.

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一碳代谢在衰老过程中肿瘤进展中的关键作用

一碳（1C）代谢是一个复杂的代谢反应网络，与产生 1C 单位（甲基）并将其用于不同的合成代谢过程密切相关，包括核苷酸合成、甲基化、蛋白质合成和还原代谢。这些途径支持了癌细胞的高增殖率。虽然针对 1C 代谢的药物（如甲氨蝶呤）已被用于癌症治疗，但它们往往有很大的副作用。因此，开发副作用最小的新药是有效治疗癌症的必要条件。蛋氨酸、甘氨酸和丝氨酸是一碳代谢的三种主要前体。一碳代谢不仅对增殖细胞至关重要，而且对非增殖细胞调节能量平衡和衰老过程也至关重要。了解一碳代谢在衰老过程中的潜在作用对于增进我们对肿瘤进展的了解至关重要。这篇综述全面介绍了癌症和衰老背景下 1C 代谢的分子复杂性，为研究人员探索开发先进的癌症治疗干预措施的新途径铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.