Activins and Inhibins in Cardiovascular Pathophysiology.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-11-18 DOI:10.3390/biom14111462

Wenyi Tang, Zhilin Gu, Jiuqi Guo, Mingzhi Lin, Hongqian Tao, Dalin Jia, Pengyu Jia

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Abstract

Activins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone. Subsequent research has demonstrated their broader biological roles across various tissue types. Primarily, activins and inhibins function through the classical TGFβ SMAD signaling pathway, but studies suggest that they also act through other pathways, with their specific signaling being complex and context-dependent. Recent research has identified significant roles for activins and inhibins in the cardiovascular system. Their actions in other systems and their signaling pathways show strong correlations with the development and progression of cardiovascular diseases, indicating potential broader roles in the cardiovascular system. This review summarizes the progress in research on the biological functions and mechanisms of activins and inhibins and their signaling pathways in cardiovascular diseases, offering new insights for the prevention and treatment of cardiovascular diseases.

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心血管病理生理学中的活性蛋白和抑制蛋白。

活性蛋白和抑制蛋白是转化生长因子β（TGFβ）超家族的成员，最初因其对卵泡刺激素分泌的相反作用而被认识。随后的研究表明，它们在各种组织类型中发挥着更广泛的生物学作用。活化素和抑制素主要通过经典的 TGFβ SMAD 信号传导途径发挥作用，但研究表明，它们也通过其他途径发挥作用，其具体的信号传导非常复杂，且取决于具体情况。最近的研究发现，活化素和抑制素在心血管系统中发挥着重要作用。它们在其他系统中的作用及其信号通路与心血管疾病的发生和发展密切相关，这表明它们在心血管系统中可能发挥更广泛的作用。本综述总结了有关活化素和抑制素及其信号通路在心血管疾病中的生物学功能和机制的研究进展，为心血管疾病的预防和治疗提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.