"A Friend Among Strangers" or the Ambiguous Roles of Runx2.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2024-10-31 DOI:10.3390/biom14111392
Kseniia Azarkina, Ekaterina Gromova, Anna Malashicheva
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引用次数: 0

Abstract

The transcription factor Runx2 plays a crucial role in regulating osteogenic differentiation and skeletal development. This factor not only controls the expression of genes involved in bone formation, but also interacts with signaling pathways such as the Notch pathway, which are essential for body development. However, studies have produced conflicting results regarding the relationship between Runx2 and the Notch pathway. Some studies suggest a synergistic interaction between these molecules, while others suggest an inhibitory one, for example, the interplay between Notch signaling, Runx2, and vitamin D3 in osteogenic differentiation and bone remodeling. The findings suggest a complex relationship between Notch signaling and osteogenic differentiation, with ongoing research needed to clarify the mechanisms involved and resolve existing contradictions regarding role of Notch in this process. Additionally, there is increasing evidence of contradictory roles for Runx2 in various tissues and organs, both under normal conditions and in pathological states. This diversity of roles makes Runx2 a potential therapeutic target, offering new directions for research. In this review, we have discussed the mechanisms of osteogenic differentiation and the important role of Runx2 in this process. We have also examined its relationship with different signaling pathways. However, there are still many uncertainties and inconsistencies in our current understanding of these interactions. Additionally, given that Runx2 is also involved in numerous other events in various tissues, we have tried to comprehensively examine its functions outside the skeletal system.

"陌生人中的朋友 "或 Runx2 的模糊角色。
转录因子 Runx2 在调节成骨分化和骨骼发育方面起着至关重要的作用。该因子不仅能控制参与骨骼形成的基因的表达,还能与Notch通路等对身体发育至关重要的信号通路相互作用。然而,有关 Runx2 与 Notch 通路之间关系的研究结果却相互矛盾。一些研究表明这些分子之间存在协同作用,而另一些研究则表明它们之间存在抑制作用,例如,Notch 信号、Runx2 和维生素 D3 在成骨分化和骨重塑过程中的相互作用。这些研究结果表明,Notch 信号与成骨分化之间存在复杂的关系,需要不断进行研究以阐明其中的机制,并解决目前关于 Notch 在这一过程中的作用的矛盾。此外,越来越多的证据表明,Runx2 在正常状态和病理状态下,在不同组织和器官中发挥着相互矛盾的作用。这种作用的多样性使 Runx2 成为潜在的治疗靶点,为研究提供了新的方向。在这篇综述中,我们讨论了成骨分化的机制以及 Runx2 在这一过程中的重要作用。我们还研究了它与不同信号通路的关系。然而,我们目前对这些相互作用的理解仍存在许多不确定性和不一致性。此外,鉴于 Runx2 还参与了各种组织中的许多其他事件,我们试图全面研究其在骨骼系统之外的功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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