Familial Pancreatic Cancer Research: Bridging Gaps in Basic Research and Clinical Application.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2024-10-30 DOI:10.3390/biom14111381
Suyakarn Archasappawat, Fatimah Al-Musawi, Peiyi Liu, EunJung Lee, Chang-Il Hwang
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引用次数: 0

Abstract

Familial pancreatic cancer (FPC) represents a significant yet underexplored area in pancreatic cancer research. Basic research efforts are notably limited, and when present, they are predominantly centered on the BRCA1 and BRCA2 mutations due to the scarcity of other genetic variants associated with FPC, leading to a limited understanding of the broader genetic landscape of FPC. This review examines the current state of FPC research, focusing on the molecular mechanisms driving pancreatic ductal adenocarcinoma (PDAC) progression. It highlights the role of homologous recombination (HR) and its therapeutic exploitation via synthetic lethality with PARP inhibitors in BRCA1/2-deficient tumors. The review discusses various pre-clinical models of FPC, including conventional two-dimensional (2D) cell lines, patient-derived organoids (PDOs), patient-derived xenografts (PDXs), and genetically engineered mouse models (GEMMs), as well as new advancements in FPC research.

家族性胰腺癌研究:缩小基础研究与临床应用之间的差距。
家族性胰腺癌(FPC)是胰腺癌研究中一个重要但尚未得到充分探索的领域。由于与家族性胰腺癌相关的其他基因变异很少,基础研究工作明显有限,即使有,也主要集中在 BRCA1 和 BRCA2 基因突变上,导致人们对家族性胰腺癌更广泛的基因状况了解有限。这篇综述探讨了 FPC 的研究现状,重点关注驱动胰腺导管腺癌 (PDAC) 进展的分子机制。它强调了同源重组(HR)的作用,以及在BRCA1/2缺陷肿瘤中通过PARP抑制剂合成致死的治疗方法。综述讨论了 FPC 的各种临床前模型,包括传统的二维 (2D) 细胞系、患者衍生的器官组织 (PDO)、患者衍生的异种移植 (PDX) 和基因工程小鼠模型 (GEMM),以及 FPC 研究的新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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