Association of prognostic nutritional index with the presence and all-cause mortality of rheumatoid arthritis: the National Health and Nutrition Examination Survey 2003-2018.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2024-11-26 DOI:10.1186/s12889-024-20795-0

Junjie Wang, Rui Zhu, Haonan Fang, Xing Xing, Liru Ge, Guoqi Cai

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引用次数: 0

Abstract

Background: The prognostic nutritional index (PNI) is a comprehensive measure of individual immune and nutritional status. This study aimed to evaluate the role of PNI in the presence and mortality of rheumatoid arthritis (RA).

Methods: This study used data of participants aged ≥ 40 years from the National Health and Nutrition Examination Survey (NHANES) 2003-2018. PNI was calculated using serum albumin and lymphocyte count. The relationship between PNI and the prevalence of RA and mortality among RA patients was assessed using logistic and Cox regression models. Nonlinear associations were explored using restricted cubic splines (RCS).

Results: Of 18,245 participants (mean 55.4 years, 49% female), 1901 had RA, among whom (480/1899, 25%) died during a median follow-up period of 84 months. PNI was inversely associated with the likelihood of having RA (odds ratio = 0.97, 95% confidence interval [CI]: 0.95-0.98). Compared to participants whose PNI was in the lowest quartile, those in other quartiles had a reduced likelihood of having RA by 21-38% (P_trend <0.01). Cox regression analysis revealed an inverse association between PNI and all-cause mortality (hazard ratio = 0.95, 95%CI: 0.91-0.99). An L-shaped association was observed between PNI and the presence and all-cause mortality of RA, with turning points occurring around the mean value of PNI. The presence and all-cause mortality of RA was significantly reduced before the turning points of PNI and plateaued afterwards.

Conclusion: In middle-aged and older adults, there is an inverse association between PNI and the presence and all-cause mortality of RA.

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预后营养指数与类风湿关节炎的存在和全因死亡率的关系：2003-2018 年全国健康与营养调查。

背景：预后营养指数（PNI预后营养指数（PNI）是衡量个体免疫和营养状况的综合指标。本研究旨在评估 PNI 在类风湿性关节炎（RA）发病和死亡中的作用：本研究使用了 2003-2018 年美国国家健康与营养调查（NHANES）中年龄≥ 40 岁的参与者的数据。PNI通过血清白蛋白和淋巴细胞计数计算得出。使用逻辑和 Cox 回归模型评估了 PNI 与 RA 患病率和 RA 患者死亡率之间的关系。使用限制性立方样条（RCS）探讨了非线性关联：在 18245 名参与者（平均 55.4 岁，49% 为女性）中，1901 人患有 RA，其中（480/1899，25%）在中位 84 个月的随访期间死亡。PNI与罹患RA的可能性成反比（几率比=0.97，95%置信区间[CI]：0.95-0.98）。与 PNI 位于最低四分位数的参与者相比，PNI 位于其他四分位数的参与者患 RA 的可能性降低了 21%-38% （Ptrend 结论）：在中老年人中，PNI 与是否患有 RA 以及 RA 的全因死亡率之间存在反比关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.