Advanced liver fibrosis, but not MASLD, is associated with accelerated biological aging: a population-based study.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2024-11-27 DOI:10.1186/s12889-024-20808-y

Chengcheng Tong, Yufeng Xue, Wei Wang, Xi Chen

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引用次数: 0

Abstract

Background: The process of biological aging in patients diagnosed with chronic liver disease remains unclear.

Aim: The current study aims to investigate if there is an accelerated biological aging process in participants with advanced fibrosis (AF) and metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: Data from the 2017-2018 NHANES cycle were analyzed. AF was determined based on the values of liver stiffness measurement (LSM) and MASLD was defined according to new consensus nomenclature. Klemera-Doubal method biological age (KDM bioage) and Phenotypic age (Phenoage) were adopted to quantify biological age. Phenoage advancement (Phenoage_advance) and KDM advancement (KDM_advance) were generated as the difference between the calculated biological age and chronological age, and a positive residual was regarded as an indicator of accelerated biological aging.

Results: A total of 3974 participants was enrolled. The weight mean KDM_advance and phenoage_advance in AF group was 4.22 years (95%CI: 2.96-5.49 years) and 2.61 years (95%CI: 1.80-3.41 years), while in MASLD group was 0.37 years (95%CI: -0.28-1.03 years) and 0.04 years (95%CI: -0.64-0.72 years), respectively. Multivariate linear regression analysis showed that participants with AF had older KDM_advance and phenoage_advance compared with those without AF (1.50 years (95%CI: 0.23-2.77 years), P = 0.02; 1.00 years (95%CI: 0.18-1.82 years), P = 0.02; respectively), in models adjusting demographic characteristics, socioeconomic status, lifestyle factors, and comorbidities. No significant association was found between MASLD and KDM_advance and phenoage_advance.

Conclusions: AF, not MASLD, was independently associated with accelerated biological aging in adults from a US representative sample.

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晚期肝纤维化（而非 MASLD）与生物老化加速有关：一项基于人群的研究。

背景：目的：本研究旨在调查晚期肝纤维化（AF）和代谢功能障碍相关性脂肪性肝病（MASLD）患者的生物衰老过程是否加速：分析了2017-2018年NHANES周期的数据。根据肝脏硬度测量值（LSM）确定AF，根据新的共识命名法定义MASLD。采用 Klemera-Doubal 法生物年龄（KDM bioage）和表型年龄（Phenoage）量化生物年龄。根据计算得出的生物年龄与年代年龄之差，得出表型年龄增长（Phenoage_advance）和KDM增长（KDM_advance），并将正残差视为生物衰老加速的指标：结果：共有 3974 人参加了研究。房颤组的KDM_advance和phenoage_advance的体重平均值分别为4.22岁（95%CI：2.96-5.49岁）和2.61岁（95%CI：1.80-3.41岁），而MASLD组的KDM_advance和phenoage_advance的体重平均值分别为0.37岁（95%CI：-0.28-1.03岁）和0.04岁（95%CI：-0.64-0.72岁）。多变量线性回归分析显示，在调整人口统计学特征、社会经济地位、生活方式因素和合并症的模型中，与无房颤的参与者相比，有房颤的参与者的KDM_提前期和phenoage_提前期更长（分别为1.50年（95%CI：0.23-2.77年），P = 0.02；1.00年（95%CI：0.18-1.82年），P = 0.02；）。在MASLD与KDM_Advance和phenoage_Advance之间没有发现明显的关联：结论：在具有代表性的美国样本中，房颤（而非MASLD）与成年人的生物衰老加速有独立关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.