Rhodium(III)-catalyzed direct C-H activation of 2-aryl-3H-indoles: a strategy for 4-heteroaryl pyrazole synthesis.

Abstract

A novel protocol for synthesizing 4-heteroaryl pyrazoles from readily available 2-aryl-3H-indoles and diazopyrazolones through the rhodium(III)-catalyzed C-H bond activation has been achieved. This redox-neutral strategy features powerful reactivity, tolerates various functional groups, and proceeds with moderate yields under mild reaction conditions.