Association between body fat percentage and depression: A cross-sectional study of NHANES

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2024-11-26 DOI:10.1016/j.jad.2024.11.066

Wenjun Gu , Kunming Bao , Xiaoming Li , Shaohang Xiang , Junhao He , Jinning He , Lixin Ye , Zhidong Huang

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引用次数: 0

Abstract

Background

Obesity and depression often co-occur and are interdependent. However, evidence regarding the association between body fat percentage in different regions and depression is scarce. Additionally, the impacts of sex-specific and BMI-stratified differences on the relationship between body fat percentage and depression remain unclear.

Methods

Data were drawn from the NHANES for the years 2005–2006 and 2011–2018. Body fat percentage was assessed using dual-energy X-ray absorptiometry (DXA). Depression was evaluated using the Patient Health Questionnaire-9 (PHQ-9). Survey-weighted binary logistic regression analyses were employed to investigate the relationship between body fat percentage and depression. Stratification analysis were stratified by sex and BMI.

Results

This study comprised 10,694 participants. Controlling confounders, the higher quartile of total body fat percentage was associated with increased OR for depression (Q4 vs Q1: OR, 1.46; 95 % CI, 1.04–2.05) as well as for leg (Q4 vs Q1: OR, 1.48; 95 % CI, 1.07–2.05), gynoid (Q4 vs Q1: OR, 1.51; 95 % CI, 1.11–2.05), subtotal (Q4 vs Q1: OR, 1.47; 95 % CI, 1.06–2.03) and head (Q3 vs Q1: OR, 1.30; 95 % CI, 1.00–1.68). In stratification analysis by sex and BMI, body fat percentage seemed to be more closely associated with depression in males or in the underweight and overweight groups.

Limitation

Cross-sectional study design and self-reported depression.

Conclusions

Elevated body fat percentage was strongly associated with higher prevalence of depression, especially in males or in the underweight and overweight groups.

查看原文本刊更多论文

体脂率与抑郁之间的关系：国家健康调查（NHANES）横断面研究

背景肥胖和抑郁常常同时存在，并且相互依存。然而，有关不同地区体脂率与抑郁症之间关系的证据却很少。此外，性别特异性和体重指数分层差异对体脂百分比与抑郁之间关系的影响仍不清楚。方法数据来自 2005-2006 年和 2011-2018 年的 NHANES。采用双能 X 射线吸收测定法（DXA）评估体脂百分比。抑郁采用患者健康问卷-9（PHQ-9）进行评估。调查加权二元逻辑回归分析用于研究体脂率与抑郁之间的关系。根据性别和体重指数进行了分层分析。在控制混杂因素的情况下，总体脂率的四分位数越高，抑郁（Q4 vs Q1：OR，1.46；95 % CI，1.04-2.05）和腿部（Q4 vs Q1：OR，1.48；95 % CI，1.07-2.05）、妇科（Q4 vs Q1：OR，1.51；95 % CI，1.11-2.05）、小腿（Q4 vs Q1：OR，1.47；95 % CI，1.06-2.03）和头部（Q3 vs Q1：OR，1.30；95 % CI，1.00-1.68）。在按性别和体重指数进行的分层分析中，男性或体重不足和超重组的体脂率似乎与抑郁症的关系更为密切。结论体脂率升高与抑郁症患病率升高密切相关，尤其是男性或体重不足和超重组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.