Synechococsins: Lanthipeptides acting as defensive signals to disarm offensive competitors?

IF 6.1 1区生物学 Q1 MICROBIOLOGY

Microbiological research Pub Date : 2024-11-17 DOI:10.1016/j.micres.2024.127965

Patricia Arias-Orozco , Rubén Cebrián , Anne de Jong , Oscar P. Kuipers

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引用次数: 0

Abstract

Synechococsins represent a diverse group of class II lanthipeptides from the prochlorosin family, produced by the marine picocyanobacterium Synechococcus. A single strain can produce multiple SyncA peptides through modification by SyncM, a bifunctional lanthipeptide synthetase. Despite the prevalence of these lanthipeptides in nature, their biological functions remain elusive, even for the most studied group, Prochlorococcus MIT9313. This study investigated the transcriptomic response of the marine SyncA-producing strain Synechococcus sp. RS9116 to the characterized and purified SyncA6 peptide from Synechococcus sp. MITS9509. Intriguingly, the analysis of gene expression revealed a strong down-regulation of genes that encode putative ribosomally produced antimicrobial peptides, such as coculture-responsive genes (CCRG-2) and microcin-C-like bacteriocins. This study suggests a potential biological role for synechococsins as interspecific gene modulators, improving the fitness of the producing strain in a competitive and resource-limited environment.

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Synechococsins：作为防御信号解除进攻性竞争者武装的表肽？

Synechococsins是海洋短色球藻（Synechococcus）产生的一组种类繁多的原氯肽家族第二类肽。一株菌株可通过 SyncM（一种双功能肽合成酶）的修饰产生多种 SyncA 肽。尽管这些硫肽在自然界中非常普遍，但它们的生物功能仍然难以捉摸，即使是研究最多的原绿球藻 MIT9313 也是如此。本研究调查了海洋 SyncA 生产菌株 Synechococcus sp.耐人寻味的是，基因表达分析表明，编码由核糖体产生的抗菌肽的基因（如共培养反应基因（CCRG-2）和类 microcin-C 细菌素）出现了强烈的下调。这项研究表明，鞘氨醇毒素作为种间基因调节剂具有潜在的生物学作用，可提高生产菌株在资源有限的竞争性环境中的适应性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiological research 生物-微生物学

CiteScore

10.90

自引率

6.00%

发文量

249

审稿时长

29 days

期刊介绍： Microbiological Research is devoted to publishing reports on prokaryotic and eukaryotic microorganisms such as yeasts, fungi, bacteria, archaea, and protozoa. Research on interactions between pathogenic microorganisms and their environment or hosts are also covered.