Regenerative medicine: Hydrogels and mesoporous silica nanoparticles

IF 8.7 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Jesús L. Pablos , Daniel Lozano , Miguel Manzano , María Vallet-Regí
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引用次数: 0

Abstract

Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility and biodegradability, closely resemble living tissues. The versatility of hydrogels has fuelled their application in various fields, such as agriculture, biomaterials, the food industry, drug delivery, tissue engineering, and regenerative medicine. Their combination with nanoparticles, specifically with Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to the next level, since MSNs could improve the hydrogel mechanical properties, their ability to encapsulate and controlled release great amounts of different therapeutic agents, and their responsiveness to a variety of external and internal stimuli. In this review, the main features of both MSNs and hydrogels are introduced, followed by the discussion of different hydrogels-MSNs structures and an overview of their use in different applications, such as drug delivery technologies and tissue engineering.

Abstract Image

再生医学:水凝胶和介孔二氧化硅纳米颗粒
水凝胶是一种交联聚合物网络,可以吸收大量的水和/或生物液体。它们具有弹性和软组织等物理特性,同时具有生物相容性和生物可降解性,与活体组织十分相似。水凝胶的多功能性促进了其在农业、生物材料、食品工业、药物输送、组织工程和再生医学等各个领域的应用。水凝胶与纳米颗粒,特别是与介孔二氧化硅纳米颗粒(MSNs)的结合将这些复合材料提升到了一个新的水平,因为 MSNs 可以改善水凝胶的机械性能、其封装和控制释放大量不同治疗剂的能力以及对各种外部和内部刺激的反应能力。在这篇综述中,首先介绍了 MSN 和水凝胶的主要特点,然后讨论了不同的水凝胶-MSN 结构,并概述了它们在不同应用中的使用,如药物输送技术和组织工程。
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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