Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2024-11-19 DOI:10.1016/j.mtbio.2024.101345

Yuqiong Xia , Chang Liu , Xuejuan Zhao , Keyun Wu , Jianxia Cao , Yutian Cao , Cheng Zhu , Xianghan Zhang

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引用次数: 0

Abstract

Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during in vivo delivery. Here, we developed an enzyme delivering nanoplatform (GCI@RPCM) with great in vivo stability and achieve NIR-triggered enzyme dynamic therapy. This nanoplatform is created with encapsulation of nature enzymes (glucose oxidase and chloroperoxidase) and photothermal agent (indocyanine green) within tumor targeting and thermo-responsive phase change materials (RPCMs). With NIR irradiation for 10 min, GCI@RPCM can release 41 % of the enzymes and generate abundant reactive oxygen species (ROS), which showed significant tumor cell inhibition. After intravenous injection, GCI@RPCM can efficiently accumulate at the tumor site and local NIR treatment resulted in complete tumor eradication without detectable systemic toxicity. This study provides a highly stable and NIR-controllable smart delivery system and achieve enzyme dynamic therapy for enhanced breast cancer therapy.

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高稳定性和近红外响应相变材料，用于癌症治疗的靶向酶输送

以天然酶为基础的催化级联在癌症治疗中受到越来越多的关注，但由于在体内传递过程中功能丧失，其临床应用受到很大限制。在此，我们开发了一种酶递送纳米平台（GCI@RPCM），它具有极高的体内稳定性，可实现近红外触发的酶动态治疗。这种纳米平台是在肿瘤靶向和热响应相变材料（RPCMs）中封装了天然酶（葡萄糖氧化酶和氯过氧化物酶）和光热剂（吲哚菁绿）。在近红外照射 10 分钟后，GCI@RPCM 可释放 41% 的酶，并产生大量活性氧（ROS），对肿瘤细胞有显著抑制作用。静脉注射后，GCI@RPCM 可在肿瘤部位有效聚集，局部近红外治疗可完全根除肿瘤，且未发现全身毒性。该研究提供了一种高度稳定且可控的近红外智能递送系统，并实现了酶动态疗法，增强了乳腺癌的治疗效果。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).