Sex differences in inter-temporal decision making and cortical thickness of the orbitofrontal and insula in young adult cannabis users: Evidence from 1111 subjects

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY
Alan N. Francis , Joan A. Camprodon , Francesca Filbey
{"title":"Sex differences in inter-temporal decision making and cortical thickness of the orbitofrontal and insula in young adult cannabis users: Evidence from 1111 subjects","authors":"Alan N. Francis ,&nbsp;Joan A. Camprodon ,&nbsp;Francesca Filbey","doi":"10.1016/j.pscychresns.2024.111919","DOIUrl":null,"url":null,"abstract":"<div><div>To test for sex differences in the impact of cannabis use on decision-making and brain correlates, we employed cortical thickness (CT) analysis of brain regions involved in intertemporal decision-making namely bilateral orbitofrontal cortex(OFC) and insula in young adult nondependent cannabis-users(CU) and non-users(NU) and their scores on delay discounting task.</div><div>Neuroimaging analyzes of previously collected data were performed on 608CU and 503NU. CT analysis was performed on MRI images. OFC and insula thickness, scores on the delay discounting test were compared between groups and correlated.</div><div>Controlling alcohol-use and intra-cranial-volume, CU exhibited sex differences in CT. The bilateral insula was significantly thinner in male CU. OFC was thinner in females relative to controls. Female CU had thinner Right-medial OFC, Left-lateral-OFC. While male CU scored significantly lower on items within delay discounting task, female CU delay-discounting scores were within normal range.</div><div>Our results demonstrate that cannabis-use differentially affects decision-making across sexes. Cortical morphology mirrors this dimorphism. CU subjects did not show a correlation between CT of OFC or insula and delay discounting, implying that thinner cortices and lower DD scores in males may be independent alterations which may be premorbid to cannabis use and may lead to cognitive deficits in later years.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"346 ","pages":"Article 111919"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry Research: Neuroimaging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0925492724001422","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

To test for sex differences in the impact of cannabis use on decision-making and brain correlates, we employed cortical thickness (CT) analysis of brain regions involved in intertemporal decision-making namely bilateral orbitofrontal cortex(OFC) and insula in young adult nondependent cannabis-users(CU) and non-users(NU) and their scores on delay discounting task.
Neuroimaging analyzes of previously collected data were performed on 608CU and 503NU. CT analysis was performed on MRI images. OFC and insula thickness, scores on the delay discounting test were compared between groups and correlated.
Controlling alcohol-use and intra-cranial-volume, CU exhibited sex differences in CT. The bilateral insula was significantly thinner in male CU. OFC was thinner in females relative to controls. Female CU had thinner Right-medial OFC, Left-lateral-OFC. While male CU scored significantly lower on items within delay discounting task, female CU delay-discounting scores were within normal range.
Our results demonstrate that cannabis-use differentially affects decision-making across sexes. Cortical morphology mirrors this dimorphism. CU subjects did not show a correlation between CT of OFC or insula and delay discounting, implying that thinner cortices and lower DD scores in males may be independent alterations which may be premorbid to cannabis use and may lead to cognitive deficits in later years.
年轻成年大麻使用者在时际决策以及眶额叶和岛叶皮层厚度方面的性别差异:来自 1111 名受试者的证据
为了检验吸食大麻对决策的影响和大脑相关性的性别差异,我们采用皮层厚度(CT)分析法,对非大麻依赖者(CU)和非吸食者(NU)中参与时际决策的大脑区域,即双侧眶额皮层(OFC)和岛叶,以及他们在延迟折现任务中的得分进行了分析。对核磁共振图像进行了 CT 分析。在控制酒精使用和颅内容积的情况下,CU 的 CT 表现出性别差异。男性 CU 的双侧脑岛明显较薄。与对照组相比,女性的大脑外协调区更薄。女性 CU 的右内侧 OFC 和左外侧 OFC 更薄。虽然男性 CU 在延迟折现任务中的项目得分明显较低,但女性 CU 的延迟折现得分在正常范围内。皮质形态反映了这种二态性。CU 受试者的大脑皮层 CT 与延迟折现之间没有相关性,这意味着男性大脑皮层较薄和延迟折现得分较低可能是独立的改变,可能是吸食大麻前的先兆,并可能导致日后的认知障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Psychiatry Research: Neuroimaging
Psychiatry Research: Neuroimaging 医学-精神病学
CiteScore
3.80
自引率
0.00%
发文量
86
审稿时长
22.5 weeks
期刊介绍: The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信