{"title":"Oxidativestress-scavenging thermo-activated MXene hydrogel for rapid repair of MRSA impaired wounds and burn wounds","authors":"Junping Ma , Sihua Li , Long Zhang , Bo Lei","doi":"10.1016/j.mattod.2024.08.010","DOIUrl":null,"url":null,"abstract":"<div><div>Rapid repair of complex skin injuries caused by multidrug-resistant bacterial infections or burn is still a challenge, due to the sustained bacterial colonization, high oxidative stress and severe inflammation. The development of efficient biomaterials strategy with precise bioactive functions is urgent in overcoming clinical challenge. In this study, we introduce a bioactive, multifunctional MXene (transition metal carbides and/or nitrides)-based hydrogel. This hydrogel, formed through the self-assembly of Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub> MXene and poly(salicylic acid)-Pluronic F127-poly(salicylic acid) (FPSa@M), exhibited the precise capabilities for regulating thermo-antioxidation and anti-inflammatory environments. FPSa@M exhibited the injectability, rapid gelation, electrical conductivity, and beneficial antioxidant and photothermal effects. The photothermal temperature-adjustable FPSa@M hydrogel effectively achieved complete photothermal eradication of high concentrations of multidrug-resistant bacteria. Additionally, FPSa@M hydrogel significantly impacted the multiple cellular behaviors, stimulating proliferation, scavenging reactive oxygen species (ROS), reducing inflammatory factor expression, promoting human umbilical vein endothelial cells (HUVECs) migration and tubule-forming activity of HUVECs. In the methicillin-resistant <em>Staphylococcus aureus</em> (MRSA)-infected or burn wound model, FPSa@M could efficiently eradicate bacterial infection, remodel the microenvironment of oxidative stress and inflammation in wound healing through activating the heat shock protein 90 and angiogenesis, thus significantly promote the wound repair. This work suggests that thermo-antioxidation activated biomaterials probably hold significant promise for addressing extensive complex tissue defects resulting from multidrug-resistant bacterial infections or burns.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 139-155"},"PeriodicalIF":21.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369702124001755","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Rapid repair of complex skin injuries caused by multidrug-resistant bacterial infections or burn is still a challenge, due to the sustained bacterial colonization, high oxidative stress and severe inflammation. The development of efficient biomaterials strategy with precise bioactive functions is urgent in overcoming clinical challenge. In this study, we introduce a bioactive, multifunctional MXene (transition metal carbides and/or nitrides)-based hydrogel. This hydrogel, formed through the self-assembly of Ti3C2TX MXene and poly(salicylic acid)-Pluronic F127-poly(salicylic acid) (FPSa@M), exhibited the precise capabilities for regulating thermo-antioxidation and anti-inflammatory environments. FPSa@M exhibited the injectability, rapid gelation, electrical conductivity, and beneficial antioxidant and photothermal effects. The photothermal temperature-adjustable FPSa@M hydrogel effectively achieved complete photothermal eradication of high concentrations of multidrug-resistant bacteria. Additionally, FPSa@M hydrogel significantly impacted the multiple cellular behaviors, stimulating proliferation, scavenging reactive oxygen species (ROS), reducing inflammatory factor expression, promoting human umbilical vein endothelial cells (HUVECs) migration and tubule-forming activity of HUVECs. In the methicillin-resistant Staphylococcus aureus (MRSA)-infected or burn wound model, FPSa@M could efficiently eradicate bacterial infection, remodel the microenvironment of oxidative stress and inflammation in wound healing through activating the heat shock protein 90 and angiogenesis, thus significantly promote the wound repair. This work suggests that thermo-antioxidation activated biomaterials probably hold significant promise for addressing extensive complex tissue defects resulting from multidrug-resistant bacterial infections or burns.
期刊介绍:
Materials Today is the leading journal in the Materials Today family, focusing on the latest and most impactful work in the materials science community. With a reputation for excellence in news and reviews, the journal has now expanded its coverage to include original research and aims to be at the forefront of the field.
We welcome comprehensive articles, short communications, and review articles from established leaders in the rapidly evolving fields of materials science and related disciplines. We strive to provide authors with rigorous peer review, fast publication, and maximum exposure for their work. While we only accept the most significant manuscripts, our speedy evaluation process ensures that there are no unnecessary publication delays.