Hyaluronic acid-based hydrogels as codelivery systems: The effect of intermolecular interactions investigated by HR-MAS and solid-state NMR Spectroscopy

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED
Valeria Vanoli , Mosè Casalegno , Marina Carravetta , Fabio Pizzetti , Andrea Mele , Filippo Rossi , Franca Castiglione
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引用次数: 0

Abstract

Hydrogels based on hyaluronic acid and agarose-carbomer, due to their peculiar 3D architecture and biocompatibility, are promising candidates for pharmaceutical strategies based on the codelivery of drugs targeting different diseases. The successful development of these applications requires a precise understanding of drug-drug interactions and their effects on transport and release mechanisms. In this study, such an investigation is carried out on hydrogels loaded with ethosuximide and sodium salicylate at different concentrations. Intermolecular interactions and transport properties are characterized by means of High Resolution Magic Angle Spinning and solid-state Magic Angle Spinning NMR Spectroscopy.
At variance with our previous findings on single-drug formulations, the two drugs exhibit closely similar diffusion patterns when co-loaded in the HA-based hydrogels, plausibly due to drug-drug intermolecular interactions. At the highest drug concentrations, where superdiffusion comes into play, we find a fraction of molecules with time-varying diffusion coefficients. A trapping-release mechanism is proposed to explain this observation, which also accounts for the role of drug-hydrogel interactions in drug diffusion motion. The effects of drug-drug interactions on release profiles are finally assessed by means of in vitro release experiments.

Abstract Image

以透明质酸为基础的水凝胶作为代码传递系统:通过 HR-MAS 和固态 NMR 光谱研究分子间相互作用的影响
基于透明质酸和琼脂糖-碳水化合物的水凝胶具有独特的三维结构和生物相容性,是针对不同疾病联合给药的制药策略的理想候选材料。要成功开发这些应用,就必须准确了解药物与药物之间的相互作用及其对转运和释放机制的影响。本研究对负载不同浓度乙琥胺和水杨酸钠的水凝胶进行了研究。与我们之前对单药制剂的研究结果不同,当两种药物共同负载在基于 HA 的水凝胶中时,它们表现出非常相似的扩散模式,这可能是由于药物分子间的相互作用。在药物浓度最高时,超扩散开始发挥作用,我们发现一部分分子的扩散系数随时间变化。我们提出了一种诱捕释放机制来解释这一观察结果,它也说明了药物-水凝胶相互作用在药物扩散运动中的作用。最后通过体外释放实验评估了药物间相互作用对释放曲线的影响。
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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