Single-cell analysis dissects heterogeneity of leukemias with complex karyotypes

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-11-27 DOI:10.1038/s41588-024-02006-z

引用次数: 0

Abstract

Chromosomal instability plays a crucial part in tumor progression, shaping cancer cell phenotypes and driving treatment resistance. We harnessed two single-cell multiomics methods to characterize the heterogeneity of acute myeloid leukemia with complex karyotype (CK-AML). Our data link genetic, non-genetic and functional heterogeneity and reveal intriguing therapeutic sensitivities.

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单细胞分析剖析复杂核型白血病的异质性

染色体不稳定性在肿瘤进展、塑造癌细胞表型和驱动耐药性方面起着至关重要的作用。我们利用两种单细胞多组学方法来描述具有复杂核型的急性髓性白血病（CK-AML）的异质性。我们的数据将遗传、非遗传和功能异质性联系起来，并揭示了耐人寻味的治疗敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution