Temporal trends and disparities in atherosclerosis-associated cerebrovascular disease mortality in the United States, 1999-2020

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-11-24 DOI:10.1016/j.cpcardiol.2024.102935

Huzaifa Ul Haq Ansari MBBS , Eman Mahboob MBBS , Muhammad Ammar Samad MBBS , Maryam Shahzad MBBS , Mushood Ahmed MBBS , Syed Tabeer Hussain Naqvi MBBS , Shurjeel Uddin Qazi MBBS , Faizan Ahmed MD , Hollie Ross-Kenny MBBS , Muath Baniowda MD , Hina Farrukh MD , Raheel Ahmed

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引用次数: 0

Abstract

Background

Cerebrovascular disease (CEVD) accounts for the second leading cause of death worldwide. Despite recent advancements in treatment strategies, the prevalence and cost associated with CEVD are rising. Atherosclerosis significantly contributes to CEVD risk by restricting cerebral blood flow, leading to ischemic stroke. This study aims to analyze trends in atherosclerosis-associated CEVD mortality in the United States from 1999 to 2020 to inform targeted prevention and management strategies.

Methods

We examined death certificates sourced from the CDC WONDER database, from 1999 to 2020 to identify atherosclerosis-associated CEVD mortality. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent changes were reported.

Results

A total of 325,401 deaths occurred from CEVD among adults with atherosclerosis from 1999 to 2020 in the US. The overall AAMR initially inclined from 10.9 in 1999 to 12.6 in 2001, followed by a decrease to 4.2 in 2016, and then a rise till 2020 was observed. Males had consistently higher AAMRs than females throughout the study period (Men = 11.9 vs Women = 10.1). When stratified by race, AAMRs were highest among non-Hispanic (NH) Whites (6.9), followed by NH American Indian/Alaska Native (10.9), NH Blacks/African Americans (6.6), Hispanics (4.9), and lastly by Asian/Pacific Islanders (4.2). The Western region had the highest mortality (AAMR: 7.7).

Conclusion

The CEVD mortality rates of adults with atherosclerosis- are increasing in the adult U.S. population. This underscores the need for increased screening, aggressive management, and subsequent surveillance of patients at risk.

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1999-2020 年美国动脉粥样硬化相关脑血管疾病死亡率趋势的逆转。

背景：脑血管疾病（CEVD）是全球第二大死亡原因。尽管最近在治疗策略方面取得了进展，但与脑血管病相关的发病率和费用仍在上升。动脉粥样硬化会限制脑血流，导致缺血性中风，从而大大增加脑血管疾病的风险。本研究旨在分析 1999 年至 2020 年美国动脉粥样硬化相关 CEVD 的死亡率趋势，为有针对性的预防和管理策略提供依据：方法：我们检查了来自美国疾病预防控制中心 WONDER 数据库的 1999 年至 2020 年死亡证明，以确定与动脉粥样硬化相关的 CEVD 死亡率。报告了每 10 万人的年龄调整死亡率（AAMRs）和每年的百分比变化：结果：1999 年至 2020 年，美国患有动脉粥样硬化的成年人中，共有 325,401 人死于 CEVD。总体AAMR最初从1999年的10.9上升到2001年的12.6，随后下降到2016年的4.2，然后一直上升到2020年。在整个研究期间，男性的 AAMR 始终高于女性（男性 = 11.9 vs 女性 = 10.1）。按种族分层时，非西班牙裔（NH）白人的急性心肌梗死死亡率最高（6.9），其次是 NH 美洲印第安人/阿拉斯加原住民（10.9）、NH 黑人/非洲裔美国人（6.6）、西班牙裔（4.9），最后是亚裔/太平洋岛民（4.2）。西部地区的死亡率最高（AAMR：7.7）：结论：在美国成年人口中，患有动脉粥样硬化的成年人的 CEVD 死亡率正在上升：结论：在美国成年人群中，动脉粥样硬化成人患者的 CEVD 死亡率正在上升：这强调了对高危患者加强筛查、积极管理和后续监测的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.