Pressure-Enabled Drug Delivery Significantly Increases Intra-Arterial Delivery of Embolic Microspheres to Liver Tumors in a Porcine Model

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Vascular and Interventional Radiology Pub Date : 2024-11-23 DOI:10.1016/j.jvir.2024.11.014

David B. Jaroch PhD , Yujia Liu PhD , Alexander Y. Kim MD , Steven C. Katz MD , Bryan F. Cox PhD , Thomas G. Hullinger PhD

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引用次数: 0

Abstract

This study aimed to test the hypothesis that pressure-enabled drug delivery (PEDD) with a pressure-modulating microcatheter device (TriNav; TriSalus Life Sciences, Westminster, Colorado) would increase delivery of microspheres via hepatic arterial infusion to liver tumors in an Oncopig model (Sus Clinicals, Chicago, Illinois) when compared with a conventional end-hole microcatheter. Trisacryl gelatin microspheres (100–300 μm in size) were fluorescently labeled and infused into porcine liver tumors using conventional technique (n = 8) or by PEDD (n = 8). Liver tissue was harvested, and images were analyzed with a custom deep learning algorithm (Visiopharm, Hørsholm, Denmark) to quantitate signal intensity. PEDD increased microsphere penetration into the tumor by 227% (P = .029) when compared with conventional methodology and improved the tumor–to–normal tissue ratio from 2.7 to 4.2. These data demonstrate improved delivery into tumor tissue using PEDD, along with improved selectivity by minimizing relative off-target deposition.

Abstract Image

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压力驱动给药 (PEDD) 在猪模型中显著提高了栓塞微球向肝脏肿瘤的动脉内给药。

本研究旨在验证一个假设，即与传统的内孔微型导管相比，在肿瘤猪模型中使用 TriNav 设备进行压力给药 (PEDD) 会增加通过肝动脉输注将胚胎球输送到肝脏肿瘤的次数。使用传统技术（8 个）或 PEDD（8 个）将荧光标记的胚球（100-300 微米大小）输注到猪肝肿瘤中。收获肝组织后，我们使用定制的 Visiopharm 深度学习算法（Visiopharm A/S）分析图像，量化信号强度。与传统方法相比，PEDD 使 Embosphere 进入肿瘤的穿透率提高了 227% (p = 0.029)，T/N 比值从 2.7 提高到 4.2。这些数据表明，使用 PEDD 能更好地向肿瘤组织输送药物，并通过最大限度地减少相对脱靶沉积提高选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular and Interventional Radiology 医学-核医学

CiteScore

4.30

自引率

10.30%

发文量

942

审稿时长

90 days

期刊介绍： JVIR, published continuously since 1990, is an international, monthly peer-reviewed interventional radiology journal. As the official journal of the Society of Interventional Radiology, JVIR is the peer-reviewed journal of choice for interventional radiologists, radiologists, cardiologists, vascular surgeons, neurosurgeons, and other clinicians who seek current and reliable information on every aspect of vascular and interventional radiology. Each issue of JVIR covers critical and cutting-edge medical minimally invasive, clinical, basic research, radiological, pathological, and socioeconomic issues of importance to the field.