David B Jaroch, Yujia Liu, Alexander Y Kim, Steven C Katz, Bryan F Cox, Thomas G Hullinger
{"title":"Pressure Enabled Drug Delivery (PEDD) Significantly Increases Intraarterial Delivery of Embolic Microspheres to Liver Tumors in a Porcine Model.","authors":"David B Jaroch, Yujia Liu, Alexander Y Kim, Steven C Katz, Bryan F Cox, Thomas G Hullinger","doi":"10.1016/j.jvir.2024.11.014","DOIUrl":null,"url":null,"abstract":"<p><p>This study aims to test the hypothesis that Pressure Enabled Drug Delivery (PEDD) with a TriNav device would increase delivery of Embospheres via hepatic artery infusion to liver tumors in an oncopig model when compared to a conventional endhole microcatheter. Embospheres (100-300um in size) were fluorescently labeled and infused into porcine liver tumors using conventional technique (n=8) or by PEDD (n=8). Liver tissue was harvested and we analyzed images with a custom Visiopharm Deep Learning algorithm (Visiopharm A/S) to quantitate signal intensity. PEDD increased Embosphere penetration into the tumor by 227% (p = 0.029) when compared to conventional methodology and improved T/N ratio from 2.7 to 4.2. These data demonstrate improved delivery into tumor tissue using PEDD, along with improved selectivity by minimizing relative off-target deposition.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Vascular and Interventional Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jvir.2024.11.014","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
Abstract
This study aims to test the hypothesis that Pressure Enabled Drug Delivery (PEDD) with a TriNav device would increase delivery of Embospheres via hepatic artery infusion to liver tumors in an oncopig model when compared to a conventional endhole microcatheter. Embospheres (100-300um in size) were fluorescently labeled and infused into porcine liver tumors using conventional technique (n=8) or by PEDD (n=8). Liver tissue was harvested and we analyzed images with a custom Visiopharm Deep Learning algorithm (Visiopharm A/S) to quantitate signal intensity. PEDD increased Embosphere penetration into the tumor by 227% (p = 0.029) when compared to conventional methodology and improved T/N ratio from 2.7 to 4.2. These data demonstrate improved delivery into tumor tissue using PEDD, along with improved selectivity by minimizing relative off-target deposition.
期刊介绍：
JVIR, published continuously since 1990, is an international, monthly peer-reviewed interventional radiology journal. As the official journal of the Society of Interventional Radiology, JVIR is the peer-reviewed journal of choice for interventional radiologists, radiologists, cardiologists, vascular surgeons, neurosurgeons, and other clinicians who seek current and reliable information on every aspect of vascular and interventional radiology. Each issue of JVIR covers critical and cutting-edge medical minimally invasive, clinical, basic research, radiological, pathological, and socioeconomic issues of importance to the field.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
