Antinuclear Positivity and Malignant Transformation Potential of Oral Potentially Malignant Disorder.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-11-25 DOI:10.1111/odi.15208

Seok Woo Hong, Jeong-Hyun Kang

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引用次数: 0

Abstract

Objective: This multicenter cohort study aimed to investigate the impact of antinuclear antibody (ANA) positivity on the malignant transformation potential of oral potentially malignant disorders (OPMDs) using the Observational Health Sciences and Informatics network tools for the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM).

Materials and methods: Retrospective cohort data from five medical centers were analyzed. Cox regression and 1:4 propensity score matching followed by aggregated meta-analysis were used to evaluate association between ANA positivity and the risk of oral squamous cell carcinoma (OSCC). The index date was defined as the first day of diagnosis of OPMD. The target and comparator cohorts comprised patients who tested positive and negative for ANA within 180 days before or after the index date, respectively.

Results: Among 27,984 OPMD patients, 1302 patients (4.65%) confirmed malignant transformation. Among these, 3035 patients had ANA laboratory data. After 1:4 PS matching, 523 and 1598 patients with positive and negative for ANA were analyzed. Meta-analysis of the hazard ratios demonstrated that ANA positivity significantly increased the risk of malignant transformation compared to ANA negativity.

Conclusions: ANA positivity is a significant prognostic marker for predicting malignant transformation in patients with OPMD.

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口腔潜在恶性疾病的抗核阳性和恶性转化潜能。

研究目的这项多中心队列研究旨在利用观察性健康科学和信息学网络工具，研究抗核抗体（ANA）阳性对口腔潜在恶性疾病（OPMDs）恶性转化可能性的影响：分析了来自五个医疗中心的回顾性队列数据。采用Cox回归和1:4倾向得分匹配，然后进行汇总荟萃分析，评估ANA阳性与口腔鳞状细胞癌（OSCC）风险之间的关联。指标日期定义为确诊口腔鳞状细胞癌的第一天。目标队列和比较队列分别包括在指数日期之前或之后 180 天内 ANA 检测呈阳性和阴性的患者：在 27984 名 OPMD 患者中，有 1302 名患者（4.65%）确诊为恶性转化。其中，3035 名患者有 ANA 实验室数据。经过 1:4 PS 匹配后，对 ANA 阳性和阴性的 523 名和 1598 名患者进行了分析。危险比的元分析表明，与ANA阴性相比，ANA阳性会显著增加恶性转化的风险：ANA阳性是预测OPMD患者恶性转化的重要预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.