Is transcutaneous auricular vagus nerve stimulation effective and safe for primary insomnia? A PRISMA-compliant protocol for a systematic review and meta-analysis.

IF 2.9 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
PLoS ONE Pub Date : 2024-11-25 eCollection Date: 2024-01-01 DOI:10.1371/journal.pone.0313101
Ting Yang, Yunhuo Cai, Xingling Li, Lianqiang Fang, Hantong Hu
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Abstract

Background: Insomnia is a highly prevalent sleep disorder with substantial impacts on health and quality of life. Current treatment options have certain limitations, highlighting the need for novel therapeutic approaches. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is gaining recognition as a promising non-invasive neuromodulation technique for treating insomnia, but its efficacy has not been systematically evaluated. Therefore, this protocol outlines the framework for a systematic review and meta-analysis designed to comprehensively assess the effectiveness and safety of ta-VNS in treating primary insomnia.

Methods: A thorough literature search will be carried out in Embase, PubMed, the Cochrane Library, PsycINFO, AMED, PEDro, Wangfang database, Chinese National Knowledge Infrastructure, and Chinese BioMedical Literature Database, covering publications from their inception until December 31, 2024. Randomized controlled trials evaluating ta-VNS for primary insomnia in adults will be included. Two independent reviewers will screen studies, gather data, and evaluate the risk of bias based on the Cochrane RoB 2.0 tool. Meta-analyses will be conducted where appropriate, and the quality of evidence will be evaluated using GRADE. Subgroup and sensitivity analyses are planned.

Discussion: This systematic review and meta-analysis will deliver a thorough synthesis of existing evidence regarding the efficacy and safety of ta-VNS for insomnia, potentially informing clinical practice and future research directions.

Trial registration: PROSPERO registration number: CRD42024529039.

经皮耳廓迷走神经刺激治疗原发性失眠有效且安全吗?符合 PRISMA 标准的系统综述和荟萃分析方案。
背景:失眠是一种非常普遍的睡眠障碍,对健康和生活质量有很大影响。目前的治疗方案有一定的局限性,因此需要新的治疗方法。经皮耳廓迷走神经刺激(ta-VNS)作为一种治疗失眠症的非侵入性神经调节技术,正逐渐得到认可,但其疗效尚未得到系统评估。因此,本方案概述了系统综述和荟萃分析的框架,旨在全面评估 ta-VNS 治疗原发性失眠症的有效性和安全性:方法:我们将在Embase、PubMed、Cochrane图书馆、PsycINFO、AMED、PEDro、王方数据库、中国国家知识基础设施和中国生物医学文献数据库中进行全面的文献检索,涵盖从开始到2024年12月31日的出版物。将纳入评估 ta-VNS 治疗成人原发性失眠的随机对照试验。两名独立审稿人将筛选研究、收集数据,并根据 Cochrane RoB 2.0 工具评估偏倚风险。适当时将进行元分析,并使用 GRADE 评估证据质量。计划进行分组分析和敏感性分析:本系统综述和荟萃分析将对有关 ta-VNS 治疗失眠症的疗效和安全性的现有证据进行全面综合,从而为临床实践和未来研究方向提供参考:试验注册:PROSPERO 注册号:CRD42024529039。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PLoS ONE
PLoS ONE 生物-生物学
CiteScore
6.20
自引率
5.40%
发文量
14242
审稿时长
3.7 months
期刊介绍: PLOS ONE is an international, peer-reviewed, open-access, online publication. PLOS ONE welcomes reports on primary research from any scientific discipline. It provides: * Open-access—freely accessible online, authors retain copyright * Fast publication times * Peer review by expert, practicing researchers * Post-publication tools to indicate quality and impact * Community-based dialogue on articles * Worldwide media coverage
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