Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2024-11-26 DOI:10.1002/iid3.70016

Matin Ghazizadeh, Elahe Roshanaie, Behrouz Barati

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引用次数: 0

Abstract

Objectives

Some changes in nasal mucus and paranasal sinuses may occur due to zinc deficiency, which can cause chronic rhinosinusitis with nasal polyps (CRSwNP). The current study was designed to compare the serum zinc concentration between patients with chronic rhinosinusitis complicated with eosinophilic or neutrophilic nasal polyps and a control group.

Methods

A total of 105 patients participated in the study. Patients in three different groups were evaluated for CRSwNP (35 in the eosinophilia group and 35 in the neutrophil group), and 35 patients underwent surgery for reasons other than polyposis (control group). The serum zinc level was determined.

Results

The mean age of the patients was 39.4 ± 12.61 years. Forty-one patients (39%) were female. Based on the enzyme linked immunosorbent assay results, the average serum zinc level in the control group was 137.01 ± 19.42 (μgm/100 mL), and in all patients with CRSwNP, it was 127.27 ± 21.7 (μgm/100 mL). The serum zinc concentration in patients with CRSwNP was significantly lower than that in the control group (p = .027). Among the CRSwNP patients with eosinophilic polyps and neutrophilic polyps, 130.42 ± 21.92 (μgm/100 mL) and 127.27 ± 21.7 (μgm/100 mL), respectively, were detected. Based on the statistical analysis, the neutrophilic and eosinophilic groups were homogenous according to the average serum zinc concentration (p = .631), and the same conditions prevailed for the eosinophilic and control groups (p = .574). There was a noticeable distinction between the neutrophilic group and the control group (p = .034).

Conclusion

Serum zinc concentrations were significantly lower in patients with neutrophilic polyps than in the general population. This difference may be due to the essential role of zinc in the inflammatory process in patients with neutrophilic polyposis.

查看原文本刊更多论文

鼻窦嗜中性粒细胞性和嗜酸性粒细胞性炎症性息肉病患者与健康人血清锌水平的比较。

目的：缺锌可能导致鼻粘膜和副鼻窦发生一些变化，从而引起慢性鼻炎并发鼻息肉（CRSwNP）。本研究旨在比较慢性鼻炎并发嗜酸性或中性鼻息肉患者与对照组的血清锌浓度：方法：共有105名患者参与了研究。方法：共有 105 名患者参加了这项研究，对三组不同的患者进行了 CRSwNP 评估（嗜酸性粒细胞组和嗜中性粒细胞组各 35 人），另有 35 名患者因息肉病以外的原因接受了手术（对照组）。对血清锌水平进行了测定：患者的平均年龄为（39.4 ± 12.61）岁。41名患者（39%）为女性。根据酶联免疫吸附试验结果，对照组患者的平均血清锌水平为 137.01 ± 19.42（微克/100 毫升），而所有 CRSwNP 患者的平均血清锌水平为 127.27 ± 21.7（微克/100 毫升）。CRSwNP 患者的血清锌浓度明显低于对照组（p = .027）。在患有嗜酸性息肉和嗜中性息肉的 CRSwNP 患者中，分别检测到 130.42 ± 21.92 (μgm/100 mL) 和 127.27 ± 21.7 (μgm/100 mL)。根据统计分析，嗜中性粒细胞组和嗜酸性粒细胞组血清锌平均浓度相同（p = .631），嗜酸性粒细胞组和对照组血清锌平均浓度相同（p = .574）。嗜中性粒细胞组与对照组之间存在明显差异（p = .034）：结论：嗜中性粒细胞息肉患者的血清锌浓度明显低于普通人群。这种差异可能是由于锌在嗜中性粒细胞性息肉病患者的炎症过程中起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology