Efficacy and Safety of Subcutaneous Unfractionated Heparin administered every 8 hours for Venous Thromboembolism Prophylaxis in Reconstructive Head and Neck Tumour Patients: A Systematic Review and 6-year Institutional Case Series.

Abstract

Background: Patients with head and neck tumours undergoing free flap reconstructions are at high risk of postoperative venous thromboembolism (VTE). To date, no specific guidelines are available regarding venous thromboembolism prophylaxis in this patient group. This study aims to contribute to this scarcity of information by reviewing the literature regarding anticoagulation regimens in this patient group and evaluating the efficacy and safety of postoperative subcutaneous heparin dosed at 5000 units every 8 hours routinely utilised at our institution.

Methods: PubMed and Embase databases were searched from inception until November 2023. Data was collected and levels of evidence were evaluated according to the Oxford Centre for Evidence Based Medicine guidelines. Additionally, a retrospective review of all patients with head and neck tumours undergoing free tissue transfer at our institution between 2015 and 2021 was performed. Patients were restricted to those receiving 5000 units of subcutaneous heparin every 8 hours postoperatively. Key outcomes included rates of VTE and surgical site haematoma.

Results: This systematic review found 15 studies eligible for inclusion ranging from 1998 to 2023. Anticoagulation regimens were markedly heterogenous. Among the literature, VTE rates reported ranged from 0% to 9.6% and bleeding rates ranged between 3.5% to 29%. Our six-year institutional analysis revealed 393 total patients. Overall, three episodes of venous thromboembolism were identified (0.76%) consisting of one deep vein thrombosis and two pulmonary emboli. The overall rate of haematoma was 9.4% with a higher rate of haematoma at the recipient site (8.1%) than the donor site (1.3%).

Conclusion: When compared to the existing literature this study found a low rate of venous thromboembolism and a comparable incidence postoperative haematoma. This suggests that 5000 units of subcutaneous heparin given every 8 hours may be a safe and effective postoperative anticoagulation regimen for these patients.