Effects of high-pressure-processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in hyperglycemic older people.

IF 4.1 2区 医学 Q2 NUTRITION & DIETETICS
Takamichi Aida, Shizue Masuki, Mayuko Morikawa, Kazumasa Manabe, Mayuka Furihata, Aki Maekawa, Tomoyuki Fujita, Hiroshi Nose
{"title":"Effects of high-pressure-processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in hyperglycemic older people.","authors":"Takamichi Aida, Shizue Masuki, Mayuko Morikawa, Kazumasa Manabe, Mayuka Furihata, Aki Maekawa, Tomoyuki Fujita, Hiroshi Nose","doi":"10.1007/s00394-024-03536-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>High-pressure-processed (HPP) rice is white rice that maintains some key functional food ingredients of brown rice, such as polyphenols. We examined whether HPP rice intake during interval walking training (IWT) improved glycemic control with enhanced methylation of the NFKB2 gene in hyperglycemic older subjects.</p><p><strong>Methods: </strong>We recruited 51 people aged ~ 70 yr who had already performed IWT for ≥ 6 months, but had hyperglycemia (blood glucose concentration ([Glc]) > 110 mg/dl or HbA1c > 6.0% while fasting). Participants were randomly divided into control (CNT) or HPP rice (HPR) groups and instructed to perform IWT for an additional 4 months while ingesting 75 g dry weight of either white rice or HPP rice, respectively, at every breakfast and dinner. Before and after intervention, [Glc] was measured by continuous glucose monitoring for 5 days, with standardized breakfast on day 5. Methylation of NFKB2 was measured by pyrosequencing.</p><p><strong>Results: </strong>After intervention, mean fasting [Glc] values for 180 min before breakfast over 4 days (days 2-5) marginally decreased in HPR but were not different from CNT (P = 0.17). However, the standard deviation during the period decreased more in HPR than in CNT (P = 0.013). Moreover, total area under the curve (tAUC) for 180 min after breakfast on day 5 decreased more in HPR than in CNT (P = 0.035). The change in tAUC on day 5 after the intervention was negatively correlated with that in NFKB2 gene methylation (P = 0.002).</p><p><strong>Conclusion: </strong>HPP rice intake during IWT improved glycemic control with suppressed reduction in NFKB2 gene methylation in hyperglycemic older people.</p><p><strong>Trial registration number and date of registration: </strong>UMIN000024390; October 13, 2016.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"26"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599310/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00394-024-03536-2","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: High-pressure-processed (HPP) rice is white rice that maintains some key functional food ingredients of brown rice, such as polyphenols. We examined whether HPP rice intake during interval walking training (IWT) improved glycemic control with enhanced methylation of the NFKB2 gene in hyperglycemic older subjects.

Methods: We recruited 51 people aged ~ 70 yr who had already performed IWT for ≥ 6 months, but had hyperglycemia (blood glucose concentration ([Glc]) > 110 mg/dl or HbA1c > 6.0% while fasting). Participants were randomly divided into control (CNT) or HPP rice (HPR) groups and instructed to perform IWT for an additional 4 months while ingesting 75 g dry weight of either white rice or HPP rice, respectively, at every breakfast and dinner. Before and after intervention, [Glc] was measured by continuous glucose monitoring for 5 days, with standardized breakfast on day 5. Methylation of NFKB2 was measured by pyrosequencing.

Results: After intervention, mean fasting [Glc] values for 180 min before breakfast over 4 days (days 2-5) marginally decreased in HPR but were not different from CNT (P = 0.17). However, the standard deviation during the period decreased more in HPR than in CNT (P = 0.013). Moreover, total area under the curve (tAUC) for 180 min after breakfast on day 5 decreased more in HPR than in CNT (P = 0.035). The change in tAUC on day 5 after the intervention was negatively correlated with that in NFKB2 gene methylation (P = 0.002).

Conclusion: HPP rice intake during IWT improved glycemic control with suppressed reduction in NFKB2 gene methylation in hyperglycemic older people.

Trial registration number and date of registration: UMIN000024390; October 13, 2016.

间歇步行训练期间摄入高压加工大米对高血糖老年人血糖控制和 NFKB2 基因甲基化的影响
目的:高压加工(HPP)大米是一种白米,它保留了糙米的一些关键功能性食品成分,如多酚。我们研究了在间歇性步行训练(IWT)期间摄入 HPP 大米是否能通过增强高血糖老年受试者 NFKB2 基因的甲基化来改善血糖控制:我们招募了 51 名年龄约为 70 岁、已进行间歇性步行训练≥ 6 个月但患有高血糖症(空腹时血糖浓度([Glc])> 110 mg/dl 或 HbA1c > 6.0%)的人。受试者被随机分为对照组(CNT)或HPP大米组(HPR),并被要求进行为期4个月的IWT,同时在早餐和晚餐时分别摄入75克干重的白米或HPP大米。在干预前后,通过连续 5 天的葡萄糖监测测量[Glc],第 5 天的早餐为标准早餐。通过热释光测序法测定 NFKB2 的甲基化程度:干预后,HPR 4 天(第 2-5 天)早餐前 180 分钟的平均空腹[Glc]值略有下降,但与 CNT 相比没有差异(P = 0.17)。然而,在此期间,HPR 的标准偏差比 CNT 下降得更多(P = 0.013)。此外,第 5 天早餐后 180 分钟的曲线下总面积(tAUC)在 HPR 比 CNT 中下降得更多(P = 0.035)。干预后第 5 天 tAUC 的变化与 NFKB2 基因甲基化的变化呈负相关(P = 0.002):结论:IWT期间摄入HPP大米可改善高血糖老年人的血糖控制,同时抑制NFKB2基因甲基化的减少:UMIN000024390;2016年10月13日。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
10.20
自引率
2.00%
发文量
295
审稿时长
6 months
期刊介绍: The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on immunology and inflammation, gene expression, metabolism, chronic diseases, or carcinogenesis, or a major focus on epidemiology, including intervention studies with healthy subjects and with patients, biofunctionality of food and food components, or the impact of diet on the environment.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信