Cancer Therapies Targeting Cellular Metabolism.

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Benjamin Morris, Alejandro Gutierrez
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引用次数: 0

Abstract

Cancer is caused by mutations that drive aberrant growth, proliferation, and invasion, thus overriding regulatory mechanisms that normally link these processes to organismal needs and cellular physiology. This imposes demands for the production of energy and biomass and for survival in microenvironments that are often nonphysiologic and nutrient-poor, which are met by rewiring of cellular metabolism. The resultant dependence of tumor cells on altered metabolism can induce sensitivity to specific metabolic perturbations that can be exploited for cancer therapy. Some cancers are caused by mutations that impart a novel function to metabolic enzymes, leading to the production of a tumor-promoting metabolite that is dispensable in normal cells, representing an ideal therapeutic target. Tumors can also exploit metabolic regulation of cellular immunity to evade antitumor immune responses, and deciphering this biology has revealed potential targets for therapeutic intervention. Here, we discuss a number of illustrative examples highlighting the therapeutic potential and the challenges of targeting metabolism for cancer therapy.

针对细胞代谢的癌症疗法。
癌症是由突变引起的,突变驱动异常生长、增殖和侵袭,从而推翻了通常将这些过程与机体需求和细胞生理联系起来的调节机制。这就对能量和生物量的生产以及在微环境中的生存提出了要求,而这些微环境往往是非生理性和缺乏营养的,需要通过重新安排细胞代谢来满足。因此,肿瘤细胞对新陈代谢改变的依赖可诱发对特定新陈代谢扰动的敏感性,从而被用于癌症治疗。有些癌症是由突变引起的,突变赋予了代谢酶一种新的功能,导致产生一种促进肿瘤生长的代谢物,而这种代谢物在正常细胞中是可有可无的,是理想的治疗靶点。肿瘤还可以利用代谢对细胞免疫的调控来逃避抗肿瘤免疫反应,对这一生物学特性的解读揭示了治疗干预的潜在靶点。在此,我们将讨论一些实例,重点介绍针对新陈代谢进行癌症治疗的潜力和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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