Charlotte Gerhard, Isabelle Masseau, Aida Vientos-Plotts, Gregory F Petroski, Carol Reinero
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引用次数: 0
Abstract
Objective: To document objective metrics of attenuation of the pulmonary parenchyma on inspiratory and expiratory breath-hold CT in dogs with bronchomalacia (BM) and dogs without BM (NoBM) using automated software analysis. Metrics included mean lung attenuation, percent low-attenuation area at -856 HU, percent high-attenuation area at -700 HU, and percent attenuation area between -600 and -250 HU.
Animals: Client-owned dogs with BM (n = 123) and NoBM (20).
Methods: This retrospective study utilized 3D Slicer software (Brigham and Women's Hospital) to assess pulmonary CT attenuation. Analysis used Spearman correlation and 2-way ANOVA with beta regression.
Results: Comparing the difference between inspiratory and expiratory phases, there was a significantly greater increase in mean lung attenuation (P = .001), a significant reduction in percent low-attenuation area at -856 HU (P = .016), and a significant increase in percent high-attenuation area at -700 HU and percent attenuation area between -600 and -250 HU (P < .001 and P < .0001, respectively) in BM versus NoBM dogs.
Conclusions: The higher inspiratory and expiratory difference in lung attenuation in BM compared to NoBM dogs supports the presence of impaired parenchymal aeration downstream of segmental and subsegmental airway collapse.
Clinical relevance: Quantitative image analysis holds promise for objectively evaluating changes with BM.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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