Body mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI:10.1111/ijpo.13186

Nikos Papadimitriou, Neil Murphy, Mazda Jenab, Zhishan Chen, Hermann Brenner, Sun-Seog Kweon, Loic Le Marchand, Victor Moreno, Elizabeth A Platz, Fränzel J B van Duijnhoven, Iona Cheng, Rish K Pai, Amanda I Phipps, Ulrike Peters, Wei Zheng, David J Hughes

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引用次数: 0

Abstract

Background: Varying obesogenic inherited predisposition in early to later life may differentially impact colorectal cancer (CRC) development. Previous Mendelian randomization (MR) studies, conducted in populations of European genetic similarity, have not observed any significant associations between early life body weight with CRC risk. However, it remains unclear whether body mass index (BMI) at different early lifetime points is causally related with CRC risk in both Europeans and East Asian populations.

Objectives: We conducted a two-sample MR study to investigate potential causal relationships between genetically predicted BMI during early life (birth to 8 years old) and at specific periods (birth, transient, early rise and late rise) and CRC risk.

Methods: Summary data were obtained from genome-wide association study (GWAS) of BMI in 28 681 children from the Norwegian Mother, Father and Child Cohort Study (MoBa) study and applied to CRC GWAS data from European and East Asian descent populations (102 893 cases and 485 083 non-cases).

Results: There were no significant associations observed between early life BMI and CRC risk in European or East Asian populations. The effect estimates were similar in European studies (odds ratio [OR] per a 1-standard deviation [SD] increase: 1.01, 95% confidence interval [CI]: 0.95, 1.07) and in East Asians (OR per a 1-SD increase: 1.02, 95% CI: 0.91, 1.14). Similar nonsignificant associations were found between time of BMI measurement during childhood and cancer-site-specific analyses.

Conclusions: We found little evidence of any associations between early life adiposity on later life CRC risk.

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出生时和生命早期的体重指数与结直肠癌：欧洲和东亚遗传相似人群的双样本孟德尔随机分析。

背景：生命早期和晚期不同的肥胖遗传易感性可能会对结直肠癌（CRC）的发展产生不同的影响。之前在欧洲遗传相似性人群中进行的孟德尔随机化（MR）研究并未观察到生命早期体重与 CRC 风险之间存在任何显著关联。然而，在欧洲和东亚人群中，不同生命早期的体重指数（BMI）是否与 CRC 风险存在因果关系仍不清楚：我们进行了一项双样本 MR 研究，以调查生命早期（出生至 8 岁）和特定时期（出生、瞬时、早期上升和晚期上升）的遗传预测 BMI 与 CRC 风险之间的潜在因果关系：从挪威母亲、父亲和儿童队列研究（MoBa）的 28 681 名儿童的 BMI 全基因组关联研究（GWAS）中获得了汇总数据，并将其应用于欧洲和东亚后裔人群的 CRC GWAS 数据（102 893 例病例和 485 083 例非病例）：结果：在欧洲和东亚人群中，均未观察到生命早期体重指数与 CRC 风险之间存在明显关联。欧洲研究中的效应估计值相似（每增加 1 个标准差的几率比 [OR]：1.01，95% 置信区间：1.01，95% 置信区间 [CI]：0.95，1.07）和东亚人（每增加 1 个标准差的比值比 [OR]：1.02，95% 置信区间 [CI]：0.91，1.14）。在儿童时期测量体重指数的时间与癌症特定地点分析之间也发现了类似的非显著性关联：我们几乎没有发现早期肥胖与日后罹患癌症风险之间有任何关联的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.