{"title":"Green eutectogel with antibacterial-sensing integration for infected wound treatment","authors":"Lingzhuang Meng \n (, ), Hui Sun \n (, ), Hongbo Zhang \n (, ), Yuyue Zhang \n (, ), Chunmei Ding \n (, ), Xinyuan Xu \n (, ), Jianshu Li \n (, )","doi":"10.1007/s40843-024-3087-4","DOIUrl":null,"url":null,"abstract":"<div><p>Hydrogels, a class of highly hydrated materials mimicking the extracellular matrix, offer tunable mechanical properties and serve as versatile platforms for functionalization, which have been used for wound dressing to prevent infection and fluid loss. However, their inherent moisture evaporation hampers both storage stability and service life in practical applications. Deep eutectic solvents (DESs), as a category of eco-friendly solvents, exhibit low vapor pressure, good conductivity, biodegradability, non-flammability, and affordability. Eutectogels using DESs as a solvent not only retain the mechanical strength and functionality of hydrogel systems but also circumvent the limitations imposed by water evaporation in conventional hydrogels, which presents a promising direction and material framework for more personalized and efficacious wound management strategies. In this study, we have successfully synthesized a novel ternary deep eutectic solvent composed of glycerol, zinc chloride, and choline chloride, and subsequently incorporated polymerizable double bonds to fabricate an eco-friendly, antimicrobial-sensing eutectogel. This gel possesses a unique combination of high mechanical strength, universal adhesion capabilities, persistent bactericidal activity, superior sensing properties, and excellent biocompatibility. Its potential application as a wound dressing was explored, with results demonstrating the ability of eutectogel to accelerate wound healing and prevent bacterial colonization at the wound site. These findings provide a solid theoretical foundation and a promising material platform for the development of next-generation intelligent wound dressings.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"67 12","pages":"3861 - 3871"},"PeriodicalIF":6.8000,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s40843-024-3087-4","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Hydrogels, a class of highly hydrated materials mimicking the extracellular matrix, offer tunable mechanical properties and serve as versatile platforms for functionalization, which have been used for wound dressing to prevent infection and fluid loss. However, their inherent moisture evaporation hampers both storage stability and service life in practical applications. Deep eutectic solvents (DESs), as a category of eco-friendly solvents, exhibit low vapor pressure, good conductivity, biodegradability, non-flammability, and affordability. Eutectogels using DESs as a solvent not only retain the mechanical strength and functionality of hydrogel systems but also circumvent the limitations imposed by water evaporation in conventional hydrogels, which presents a promising direction and material framework for more personalized and efficacious wound management strategies. In this study, we have successfully synthesized a novel ternary deep eutectic solvent composed of glycerol, zinc chloride, and choline chloride, and subsequently incorporated polymerizable double bonds to fabricate an eco-friendly, antimicrobial-sensing eutectogel. This gel possesses a unique combination of high mechanical strength, universal adhesion capabilities, persistent bactericidal activity, superior sensing properties, and excellent biocompatibility. Its potential application as a wound dressing was explored, with results demonstrating the ability of eutectogel to accelerate wound healing and prevent bacterial colonization at the wound site. These findings provide a solid theoretical foundation and a promising material platform for the development of next-generation intelligent wound dressings.
水凝胶是一类模仿细胞外基质的高水合材料,具有可调的机械特性,是功能化的多功能平台,已被用于伤口敷料,以防止感染和液体流失。然而,它们固有的水分蒸发特性阻碍了实际应用中的储存稳定性和使用寿命。深共晶溶剂(DES)是一种环保溶剂,具有蒸汽压低、导电性好、可生物降解、不易燃、价格低廉等特点。以 DESs 为溶剂的共晶凝胶不仅能保持水凝胶系统的机械强度和功能性,还能规避传统水凝胶中水分蒸发所带来的限制,这为更个性化、更有效的伤口管理策略提供了一个前景广阔的方向和材料框架。在这项研究中,我们成功合成了一种由甘油、氯化锌和氯化胆碱组成的新型三元深共晶溶剂,随后加入了可聚合双键,制成了一种环保型抗菌传感共晶凝胶。这种凝胶具有独特的高机械强度、普遍的粘附能力、持久的杀菌活性、优异的传感性能和出色的生物相容性。研究人员对其作为伤口敷料的潜在应用进行了探索,结果表明优特凝胶能够加速伤口愈合并防止细菌在伤口部位定植。这些发现为开发下一代智能伤口敷料提供了坚实的理论基础和前景广阔的材料平台。
期刊介绍:
Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.