3D imaging of the synovium defines an immune defense system at the blood–joint barrier

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-11-25 DOI:10.1038/s41590-024-02016-3

引用次数: 0

Abstract

Circulating immune stimuli access the joint through fenestrated capillaries that are located at the outer edge of the synovium. This area of vulnerability is policed by interacting macrophages and nociceptor neurons that work together as a functional unit.

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滑膜的三维成像确定了血-关节屏障的免疫防御系统

循环免疫刺激通过位于滑膜外缘的毛细血管进入关节。这一脆弱区域由相互作用的巨噬细胞和痛觉神经元作为一个功能单元进行监控。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.