Base‐Mediated Sequential Annulation Reaction of Conjugated Dienes and Crotonate‐Derived Sulfur Ylides: Effective Synthesis of Bicyclo[4.1.0]heptenes

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-04 DOI:10.1002/adsc.202401273

Zhenjie Gan , Jingran Sun , Zhangyun Huang , Zhenjue Cai , Yue Wang , Er‐Qing Li

引用次数: 0

Abstract

Herein we present a method for base‐mediated sequential annulation reaction of conjugated dienes. The method offers an efficient pathway for the effective construction of bicyclo[4.1.0]heptenes. Notable features of this approach include good yields, remarkable stereoselectivity, as well as a broad substrate scope and significant step efficiency. In addition, the reaction could be effectively scaled up to a gram scale under standard condition.

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碱介导的共轭二烯与巴豆酸盐衍生硫酰的序贯环化反应：双环[4.1.0]庚烯的有效合成

在此，我们提出了一种以碱为介导的共轭二烯顺序环化反应方法。该方法为有效构建双环[4.1.0]庚烯提供了一条高效途径。该方法的显著特点包括产率高、立体选择性显著、底物范围广以及步骤效率高。此外，在标准条件下，该反应可以有效地放大到克级规模。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.