Traditional Chinese Medicine: A Promising Treatment Option for Intestinal Fibrosis.

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-11-25 DOI:10.1142/S0192415X24500812
Meng'en Zhou, Yan Chen, Wenqi Jin, Peng Li, Jie Hu, Xiutian Guo
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Abstract

Intestinal fibrosis, a common complication of inflammatory bowel disease, in particular in Crohn's disease, arises from chronic inflammation, leading to intestinal narrowing, structural damage, and functional impairment that significantly impact patients' quality of life. Current treatment options for intestinal fibrosis are limited, with surgery being the primary intervention. Traditional Chinese Medicine (TCM) has emerged as a promising approach in preventing and treating intestinal fibrosis. However, there is a scarcity of literature summarizing the mechanisms underlying TCM's efficacy in this context. To address this gap, we conducted a comprehensive review, uncovering multiple mechanisms through which TCM mitigates intestinal fibrosis. These mechanisms include immune cell balance regulation, suppression of inflammatory responses, reduction of inflammatory mediators, alleviation of colon tissue damage, restoration of intestinal function, modulation of growth factors to inhibit fibroblast activation, dynamic regulation of TIMPs and MMPs to reduce extracellular matrix deposition, inhibition of epithelial-mesenchymal transition and endothelial-mesenchymal transition, autophagy modulation, maintenance of the intestinal mucosal barrier, prevention of tissue damage by harmful factors, and regulation of cell proliferation and apoptosis. This study aims to bridge existing knowledge gaps by presenting recent evidence supporting the utilization of TCM in both clinical and experimental research settings.

中医药:中药:治疗肠纤维化的有效方法。
肠纤维化是炎症性肠病(尤其是克罗恩病)的常见并发症,由慢性炎症引起,导致肠道狭窄、结构损伤和功能障碍,严重影响患者的生活质量。目前治疗肠纤维化的方法有限,手术是主要的干预手段。中医药已成为预防和治疗肠纤维化的一种很有前景的方法。然而,总结中医药在这方面疗效机制的文献却很少。为了填补这一空白,我们进行了全面综述,发现了中医药缓解肠纤维化的多种机制。这些机制包括调节免疫细胞平衡、抑制炎症反应、减少炎症介质、减轻结肠组织损伤、恢复肠道功能、调节生长因子以抑制成纤维细胞活化、动态调节 TIMPs 和 MMPs 以减少细胞外基质沉积、抑制上皮-间充质转化和内皮-间充质转化、自噬调节、维护肠粘膜屏障、防止有害因素对组织的损伤以及调节细胞增殖和凋亡。本研究旨在通过介绍支持在临床和实验研究环境中使用中药的最新证据,弥补现有的知识差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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