A Multivariate and Network Analysis Uncovers a Long-Term Influence of Exclusive Breastfeeding on the Development of Brain Morphology and Structural Connectivity.

IF 2.3 3区 医学 Q3 CLINICAL NEUROLOGY
Fabrizio Parente, Tiziana Pedale, Camilla Rossi-Espagnet, Daniela Longo, Antonio Napolitano, Simone Gazzellini, Simone Macrì, Valerio Santangelo
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引用次数: 0

Abstract

Exclusive breastfeeding (eBF) in infancy appears to offer a developmental advantage for children's brains compared to formula-fed counterparts. Existing research has predominantly focused on global brain measures (i.e., total white/grey matter volumes) or on limited sets of specific brain regions, in selected age groups, leaving uncertainties about the impact of eBF on the overall structural connectomes. In this cross-sectional study encompassing participants from childhood to adulthood, partial least squares correlations (PLSC) were employed to assess white and grey matter volumes. Furthermore, a network analytic approach was used to estimate the structural connectome based on cortical thickness data. The results revealed that eBF duration correlated with increased white matter volumes in children and with the volume of the medial orbital gyrus in adults. Structural connectome analyses demonstrated heightened anatomical connectivity in eBF children, evidenced by enhanced network density and local/global efficiency, along with increased node degree and local efficiency in frontal and temporal lobes. Similarly, eBF in adults was associated to an improved node connectivity in the frontal lobe. These findings imply a lasting impact of eBF on brain morphometry and structural connectivity. Childhood benefits include heightened white matter development, while in adulthood, eBF may contribute to reduced neural loss associated with aging and enhanced connectivity, particularly in frontal regions.

多元和网络分析揭示了纯母乳喂养对大脑形态和结构连接发育的长期影响。
与配方奶粉喂养的婴儿相比,婴儿期纯母乳喂养(eBF)似乎为儿童大脑的发育提供了优势。现有的研究主要集中在选定年龄组的整体大脑测量(即白质/灰质总体积)或有限的特定大脑区域,因此还不确定纯母乳喂养对整体结构连接组的影响。在这项横断面研究中,研究人员采用偏最小二乘法相关性(PLSC)来评估白质和灰质体积。此外,研究还采用了一种网络分析方法,根据皮质厚度数据估算结构连接组。结果显示,eBF持续时间与儿童白质体积的增加和成人眶内侧回体积的增加相关。结构连接组分析表明,eBF 儿童的解剖连接性增强,表现为网络密度和局部/全局效率提高,额叶和颞叶的节点度和局部效率提高。同样,成人 eBF 也与额叶节点连接的改善有关。这些研究结果表明,eBF 对大脑形态测量和结构连接具有持久的影响。儿童期的益处包括白质发育增强,而在成年期,eBF可能有助于减少与衰老相关的神经损失和增强连接性,尤其是在额叶区域。
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来源期刊
Brain Topography
Brain Topography 医学-临床神经学
CiteScore
4.70
自引率
7.40%
发文量
41
审稿时长
3 months
期刊介绍: Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.
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