Context-dependent orientation discontinuity encoding by gamma rhythms in mouse primary visual cortex

Abstract

Through the modulation of its surround, an identical visual stimulus can be perceived as more or less salient, allowing it to either stand out or seamlessly integrate with the rest of the visual scene. Gamma rhythms are associated with processing stimulus features across extensive areas of the visual field. Consistent with this concept, the magnitude of visually induced gamma rhythm depends on how well stimulus features aligned both within and outside the classical receptive field (CRF) at the recording site. However, there still exists some uncertainty regarding the encoding of context-modulated orientation discontinuity by gamma rhythms. To address this concern, we conducted extracellular recordings in layers II/III and IV of area V1 using lightly anaesthetized mice to investigate the gamma tuning for stimuli with orientation discontinuity. Our study revealed that gamma rhythms exhibit a preference for stimuli with orientation discontinuity similar to the spiking responses observed in V1, which contradicts the findings of previous studies. Furthermore, the gamma tuning of discontinuous orientations exhibits a moderate correlation with spike tuning and a positive correlation with the strength of surround suppression. Therefore, our study suggests a close association between gamma tuning and nearby spiking tuning; additionally, it highlights the connection between the encoding of visual features by gamma rhythms and functional architecture, as well as neural signal integration.

Key points

• Visual context modulates the gamma rhythms in the primary visual cortex.
• Discontinuous orientation elicits significantly enhanced gamma rhythms compared to the iso-orientation stimulus.
• The gamma tuning of discontinuous orientations exhibits a moderate correlation with spike tuning.
• Gamma tuning of orientation discontinuity exhibits a positive correlation with the strength of surround suppression.