Evaluate the Serum of Irisin, Omentin-1, and Oxidative Status in Males with Prostatic Cancer.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Reports of Biochemistry and Molecular Biology Pub Date : 2024-04-01 DOI:10.61186/rbmb.13.1.23

Malik Musa Sultan, Talib Hussein Abdullah, Mohammed Abbas Abdullah, Waleed Al-Darkazali, Nazar Sattar Harbi

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引用次数: 0

Abstract

Background: Prostate cancer is a classic public health problem in males and has broadly different levels of mortality and morbidity. As an endocrine gland, adipose tissue synthesizes and secretes a variety of bioactive peptides, such as irisin and omentin-1. Adipokines and oxidative stress potentially contribute to the proliferation of prostatic carcinoma cells. The relationship between irisin, omentin-1, and oxidative stress has not been widely investigated in prostate cancer. Therefore, the present research assessed whether there is a significant correlation between irisin and omentin-1 levels and oxidative status in prostate cancer individuals.

Methods: The present research recruited 40 individuals diagnosed with prostate cancer and 40 healthy individuals for comparative purposes. All individuals underwent demographics, biochemicals, and serum adipokines (irisin and omentin-1) data analysis.

Results: The means of total prostate-specific antigen (43.3±20.5 vs. 2.5±1.2) and free prostate-specific antigen (2.1±1.4 vs. 0.08±0.02) were highly significant increases in the prostate cancer patients than in the healthy individuals. Furthermore, the means of omentin-1 (31.6±12.8 vs. 23.5±14.1) and total oxidant stress (22.4±10.6 vs. 9.1±3.6) were highly significant increases in patients with prostate cancer than in healthy individuals. In contrast, the means of irisin (343.5±240.2 vs. 716.4±142.3) and total antioxidant capacity (2.2±1.2 vs. 3.3±1.3) were highly significant decreases in patients with prostate cancer than in healthy individuals. No significant relationship was demonstrated between all parameters in the two groups under study.

Conclusions: The study findings indicate that irisin and omentin-1 could serve as biomarkers for predicting prostate cancer.

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评估男性前列腺癌患者血清中的鸢尾素、网织蛋白-1和氧化状态

背景：前列腺癌是男性的典型公共卫生问题，其死亡率和发病率有很大差异。作为一种内分泌腺，脂肪组织可合成和分泌多种生物活性肽，如鸢尾素和网膜素-1。脂肪因子和氧化应激可能会导致前列腺癌细胞的增殖。鸢尾素、网织蛋白-1 和氧化应激之间的关系尚未在前列腺癌中得到广泛研究。因此，本研究评估了前列腺癌患者体内鸢尾素和网织红蛋白-1水平与氧化状态之间是否存在显著相关性：方法：本研究招募了 40 名确诊为前列腺癌的患者和 40 名健康患者进行比较。结果：前列腺癌患者的前列腺特异性抗原（PSA）总平均值和网织红蛋白-1（Omentin-1）总平均值均高于健康人：结果：前列腺癌患者的前列腺特异性抗原总量（43.3±20.5 vs. 2.5±1.2）和游离前列腺特异性抗原总量（2.1±1.4 vs. 0.08±0.02）均比健康人显著增加。此外，前列腺癌患者的网织红蛋白-1（31.6±12.8 vs. 23.5±14.1）和总氧化应激（22.4±10.6 vs. 9.1±3.6）均比健康人显著增加。相比之下，前列腺癌患者的鸢尾素（343.5±240.2 vs. 716.4±142.3）和总抗氧化能力（2.2±1.2 vs. 3.3±1.3）均显著低于健康人。研究中两组患者的所有参数之间均无明显关系：研究结果表明，鸢尾素和网膜素-1可作为预测前列腺癌的生物标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.