Changes in Circadian Timing Following a One-Week In-Home Sleep Extension Manipulation in Habitually Short-Sleeping Adolescents.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-11-25 DOI:10.1093/sleep/zsae273

Sydney Holtman, Emily Cooper, John T Brinton, Anne E Bowen, Stephen Hawkins, Melanie G Cree, Kristen J Nadeau, Kenneth P Wright, Stacey L Simon

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引用次数: 0

Abstract

Study objectives: Evaluate objectively-measured circadian rhythms following one-week of at-home sleep extension in habitually short-sleeping adolescents.

Methods: Twenty-six participants (16.1±1.2 years, 69% female, and 65% White Non-Hispanic) with insufficient sleep (<7 hours on school nights) were randomized to one week of typical sleep (TS; usual school schedule) and sleep extension (EXT; ≥1-hour additional time in bed) in counterbalanced order with a 1-month washout between conditions. Home monitoring of actigraphy-estimated sleep and light exposure was assessed during both weeks. Hourly in-laboratory evening/morning dim-light salivary melatonin samples were obtained and onset (DLMOn) and offset (DLMOff) were calculated following each condition.

Results: Sleep duration increased by 1.37 hours (95% CI: 1.09, 1.66; p<0.001), bedtimes advanced by 1.40 (95% CI: -1.75, -1.06; p<0.001), and waketimes did not significantly change (p=0.055) during EXT compared to TS. There was no change in DLMOn or DLMOff following EXT (both p>0.05). The DLMOn-sleep onset phase angle narrowed by 0.72 hours (95% CI: -1.39, -0.07; p=0.04) during EXT. Light exposure within 2-hours of bedtime was significantly higher during EXT compared to TS (23.37 vs. 7.73 lux; p=0.048).

Conclusion: Sleep extension did not change melatonin onset or offset but may have increased circadian alignment. Further research should evaluate the addition of specific strategies to improve circadian timing such as morning bright light in combination with sleep extension.

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对习惯性短睡眠的青少年进行为期一周的居家睡眠延长操作后昼夜节律时间的变化。

研究目的对习惯性睡眠不足的青少年进行为期一周的居家睡眠延长后，评估客观测量的昼夜节律：研究对象： 26 名睡眠不足的青少年（16.1±1.2 岁，69% 为女性，65% 为非西班牙裔白人）：睡眠时间增加了 1.37 小时（95% CI：1.09, 1.66；P0.05）。在 EXT 期间，DLMOn-睡眠开始相位角缩小了 0.72 小时（95% CI：-1.39，-0.07；P=0.04）。与TS相比，EXT期间睡前2小时内的光照显著更高（23.37 vs. 7.73勒克斯；p=0.048）：结论：延长睡眠时间不会改变褪黑激素的起始或偏移，但可能会提高昼夜节律的一致性。进一步的研究应评估增加特定策略以改善昼夜节律的时间安排，如将早晨的强光与延长睡眠时间相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.