Androgen Receptor and Non-Coding RNAs' Interaction in Renal Cell Carcinoma.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-Coding RNA Pub Date : 2024-11-12 DOI:10.3390/ncrna10060056

Manal A Hussain, Noha M Elemam, Iman M Talaat

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Abstract

Renal cell carcinoma (RCC), the most prevalent among the urogenital cancers, accounts for around 3% of new cancer cases worldwide. Significantly, the incidence of RCC has doubled in developed world countries, ranking it as the sixth most common cancer in males, who represent two-thirds of RCC cases. Males with RCC exhibit a higher mortality rate and tend to develop a more aggressive form of the disease than females. Sex-related risk factors, including lifestyle and biological variations, explain this difference. The androgen receptor (AR) oncogenic signaling pathway has been extensively studied among the biological factors that affect RCC. Recent advancements in high-throughput RNA sequencing techniques have underscored the significant roles played by noncoding-RNAs (ncRNAs), previously dismissed as "junk". The oncogenic potential of AR is manifested through its dysregulation of the ncRNAs' availability and function, promoting RCC tumorigenesis. This review offers a summary of the most recent findings on the role and molecular mechanisms of the AR in dysregulating the ncRNAs that play a role in the progression of RCC and the possibility of utilizing ncRNAs to target AR as a potential therapeutic strategy.

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肾细胞癌中雄激素受体与非编码 RNA 的相互作用

肾细胞癌（RCC）是泌尿生殖系统癌症中最常见的一种，约占全球新发癌症病例的 3%。值得注意的是，在发达国家，RCC 的发病率已翻了一番，在男性癌症中排名第六，而男性占 RCC 病例的三分之二。与女性相比，男性 RCC 患者的死亡率更高，而且病情往往更具侵袭性。与性别相关的风险因素，包括生活方式和生理变化，是造成这种差异的原因。在影响 RCC 的生物因素中，雄激素受体（AR）致癌信号通路已被广泛研究。高通量 RNA 测序技术的最新进展凸显了以前被视为 "垃圾 "的非编码 RNA（ncRNA）的重要作用。AR 的致癌潜能体现在其对 ncRNA 的可用性和功能的失调，从而促进 RCC 肿瘤的发生。本综述概述了 AR 在抑制 ncRNAs 方面的作用和分子机制，这些 ncRNAs 在 RCC 的发展过程中发挥着重要作用，以及利用 ncRNAs 靶向 AR 作为潜在治疗策略的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.