Association of Apical Periodontitis with Glycated Hemoglobin Levels and Systemic Inflammatory Markers in Patients with Type 2 Diabetes: A Cross-Sectional Study

IF 3.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics Pub Date : 2025-02-01 DOI:10.1016/j.joen.2024.11.008

Ritika Dhamija MDS , Sanjay Tewari MDS , Paramjeet Singh Gill MD , Nitika Monga MDS , Shweta Mittal MDS , Jigyasa Duhan MDS

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Abstract

Introduction

This cross-sectional study, as a preliminary part of an ongoing project, aimed to investigate the effect of apical peridontitis (AP) on glycated hemoglobin (HbA1c) and systemic inflammatory markers in diabetic individuals.

Methods

A total of 280 individuals (140 with type 2 diabetes mellitus [T2DM] and 140 healthy) with and without AP were enrolled. Sixty-four age-, gender-, and body mass index–matched participants each in T2DM with AP group (DAP), T2DM without apical periodontitis (D), systemically healthy controls with apical periodontitis (CAP), and without apical periodontitis (C) groups were evaluated. Radiologic and clinical oral examination was performed for confirming the diagnosis of AP and periapical index scoring (PAI). Blood analyses were carried out for interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, high-sensitivity C-reactive protein (hsCRP), and HbA1c assessment.

Results

Significantly higher levels of IL-1β, TNF-α, and hsCRP were observed in patients with AP in both diabetes and control groups (P < .05). In the diabetes group, AP contributed to significantly raised levels of HbA1c compared with T2DM group patients without AP. After controlling for possible confounders, partial corelation coefficients revealed positive corelation of presence of AP as well as size of the periapical lesion with HbA1c and serum levels of inflammatory markers in both diabetic and healthy individuals. Multivariate linear regression analysis revealed both presence of AP (P < .05) as well as the size of lesion (P < .001) were found to significantly predict the HbA1c levels as well as the levels of IL-1β, IL-6, TNF-α, and hsCRP in both diabetic and non-diabetic individuals.

Conclusions

These findings suggest that both presence of AP and size of periapical lesion was associated with glycemic control and systemic inflammatory burden in patients with T2DM.

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2 型糖尿病患者根尖牙周炎与糖化血红蛋白水平和全身炎症指标的关系：一项横断面研究。

简介这项横断面研究是正在进行的项目的一个初步部分，旨在调查牙髓尖周炎对糖尿病患者糖化血红蛋白（HbA1c）和全身炎症指标的影响。对患有牙根尖牙周炎的 T2DM 组（DAP）、未患有牙根尖牙周炎的 T2DM 组（D）、患有牙根尖牙周炎的系统健康对照组（CAP）和未患有牙根尖牙周炎的系统健康对照组（C）各 64 名年龄、性别和体重指数相匹配的参与者进行了评估。为确诊 AP 和根尖周指数评分 (PAI)，进行了放射学和临床口腔检查。对血液中的 IL-1β、IL-6、TNF-α、hsCRP 和 HbA1c 进行了分析：结果：在糖尿病组和对照组中，均观察到 AP 患者的 IL-1β、TNF-α 和 hsCRP 水平明显升高（p 结论：这些研究结果表明，AP 患者和糖尿病组患者的 IL-1β、TNF-α 和 hsCRP 水平均明显升高：这些研究结果表明，AP 的存在和根尖周病变的大小与 T2DM 患者的血糖控制和全身炎症负担有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.