{"title":"Vicious cycle of vitamin B<sub>1</sub> insufficiency and heart failure in cardiology outpatients.","authors":"Misora Ao, Kensuke Takabayashi, Rika Tomita, Ryoko Fujita, Takashi Miyawaki, Kiyoshi Tanaka","doi":"10.3164/jcbn.24-137","DOIUrl":null,"url":null,"abstract":"<p><p>Heart failure is a major manifestation of vitamin B<sub>1</sub> deficiency; beriberi. We have previously reported that even vitamin B<sub>1</sub> insufficiency, milder than deficiency, is a risk for heart failure in the institutionalized elderly. Then in this cross-sectional study, sixty-eight cardiology outpatients were evaluated for their whole blood vitamin B<sub>1</sub> and plasma brain natriuretic peptide (BNP) concentrations, a sensitive marker of heart failure, as well as their dietary intake. Whole blood vitamin B<sub>1</sub> concentration was significantly correlated with plasma BNP level in vitamin B<sub>1</sub>-deficient/insufficient patients (whole blood vitamin B<sub>1</sub><28 ng/ml) but not in sufficient patients. Whole blood vitamin B<sub>1</sub> concentration was significantly lower in loop diuretics users than non-users. Multiple regression analysis has identified whole blood vitamin B<sub>1</sub> concentration and eGFR as the significant contributors to log-transformed plasm BNP level, and loop diuretics use, serum albumin level, and eGFR as the contributors to whole blood vitamin B<sub>1</sub> concentration. ROC analysis has shown the significant predictability of whole blood vitamin B<sub>1</sub> for plasma BNP ≥100 pg/ml with the cut-off value of 23.5 ng/ml. Vitamin B<sub>1</sub> insufficiency is a risk of heart failure in the cardiology outpatients, and the therapeutic use of loop diuretics aggravates heart failure and possibly forms a vicious cycle.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"75 3","pages":"241-246"},"PeriodicalIF":2.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579856/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Biochemistry and Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3164/jcbn.24-137","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
Heart failure is a major manifestation of vitamin B1 deficiency; beriberi. We have previously reported that even vitamin B1 insufficiency, milder than deficiency, is a risk for heart failure in the institutionalized elderly. Then in this cross-sectional study, sixty-eight cardiology outpatients were evaluated for their whole blood vitamin B1 and plasma brain natriuretic peptide (BNP) concentrations, a sensitive marker of heart failure, as well as their dietary intake. Whole blood vitamin B1 concentration was significantly correlated with plasma BNP level in vitamin B1-deficient/insufficient patients (whole blood vitamin B1<28 ng/ml) but not in sufficient patients. Whole blood vitamin B1 concentration was significantly lower in loop diuretics users than non-users. Multiple regression analysis has identified whole blood vitamin B1 concentration and eGFR as the significant contributors to log-transformed plasm BNP level, and loop diuretics use, serum albumin level, and eGFR as the contributors to whole blood vitamin B1 concentration. ROC analysis has shown the significant predictability of whole blood vitamin B1 for plasma BNP ≥100 pg/ml with the cut-off value of 23.5 ng/ml. Vitamin B1 insufficiency is a risk of heart failure in the cardiology outpatients, and the therapeutic use of loop diuretics aggravates heart failure and possibly forms a vicious cycle.
期刊介绍:
Journal of Clinical Biochemistry and Nutrition (JCBN) is
an international, interdisciplinary publication encompassing
chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The
Journal welcomes original contributions dealing with all
aspects of clinical biochemistry and clinical nutrition
including both in vitro and in vivo studies.