Female patients with end-stage renal failure treated by hemodialysis had a low mortality rate and small patient number compared to male patients: 5-year follow-up study in Japan.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI:10.3164/jcbn.24-141
Kuniyasu Takagi, Takuya Kishi, Taku Goto, Kohei Yamanouchi, Kazuhiko Yoshikawa, Tomohiro Imamura, Shiki Nakayama, Keizo Anzai, Yuichiro Akiyoshi, Akira Kitajima, Koji Onozawa, Ayako Takamori, Kazuma Fujimoto
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引用次数: 0

Abstract

This study aimed to evaluate gender differences of hemodialysis patients in adverse events, gastrointestinal bleeding, and bone fractures during 5 year longitudinal follow-up period in the regional core hospital in Japan. This study included 151 patients with maintenance hemodialysis for end-stage renal failure at Takagi Hospital in December 2017. All the patients, divided into females-group of 61 and males-group of 90. Data were evaluated in the electronic medical record. Multivariate analysis indicated a decrease in diabetes mellitus (odd ratio: 2.3, 95% confidence interval: 1.1-4.8, p = 0.03) and less mortality in those younger than 75 years old (odd ratio: 0.2, 95% confidence interval: 0.1-0.8, p = 0.02) were characterized factors in females. Gastrointestinal bleeding were not different between genders. Bone fractures were high in females (females: 34.4% vs males: 18.9%; p<0.03), whereas the mortality rate of bone fractured patients was markedly high in males (females: 28.6% vs males: 76.5%; p = 0.003) with lower body bone fractures. In conclusion, diabetes mellitus-induced end-stage renal failure was less common in females. The mortality rate during hemodialysis was higher in males less than 75 years old with increased mortality with lower bone fractures.

与男性患者相比,接受血液透析治疗的终末期肾衰竭女性患者死亡率低、人数少:日本 5 年随访研究。
本研究旨在评估日本地区核心医院5年纵向随访期间血液透析患者在不良事件、消化道出血和骨折方面的性别差异。本研究纳入了2017年12月在高木医院接受终末期肾衰竭维持性血液透析的151名患者。所有患者分为女性组61人和男性组90人。数据通过电子病历进行评估。多变量分析表明,女性糖尿病患者减少(奇数比:2.3,95%置信区间:1.1-4.8,P = 0.03)和75岁以下患者死亡率降低(奇数比:0.2,95%置信区间:0.1-0.8,P = 0.02)是特征性因素。消化道出血在性别上没有差异。女性骨折率较高(女性:34.4%,男性:18.9%;pp = 0.003),全身骨折率较低。总之,糖尿病引发的终末期肾衰竭在女性中较少见。75岁以下男性在血液透析期间的死亡率较高,骨折程度较轻的患者死亡率也较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
8.30%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.
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