Retromode Infrared Scanning Laser Ophthalmoscopy in Vogt-Koyanagi-Harada Disease.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2024-11-25 DOI:10.1007/s00417-024-06693-6

Shintaro Yasuda, Takeshi Yoshida, Yudai Suzuki, Yuiko Sugahara, Junfuku Lee, Koju Kamoi, Shintaro Horie, Hiroshi Takase, Kyoko Ohno-Matsui

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引用次数: 0

Abstract

Purpose: This study examined six patients with Vogt-Koyanagi-Harada (VKH) disease using retromode infrared scanning laser ophthalmoscopy (RMI-SLO).

Methods: We conducted a single-center retrospective review of the medical records of six patients diagnosed with VKH disease. The RMI-SLO images were compared to those obtained using color fundus photography, optical coherence tomography (OCT), and dye-based retinal angiography.

Results: In the acute phase of VKH disease, RMI-SLO revealed pseudo-three-dimensional (3D) regions and wavy patterns. These observations corresponded to the areas of serous retinal detachment (sRD) and choroidal folds identified on OCT. Notably, the detection of pseudo-3D regions by RMI-SLO proved to be more effective than color fundus photography in identifying sRDs. Hyper-reflective lines inside the sRDs were observed in the RMI-SLO images and were consistent with the fibrinous membranes observed in the OCT images. The hyper-reflective choroidal vasculature in RMI-SLO images was notably absent, a finding like the fuzzy pattern of large stromal choroidal vessels observed in indocyanine green angiography images. Following steroid treatment, these abnormal findings reverted to normal.

Conclusions: RMI-SLO imaging could serve as an alternative option for both pre- and post-treatment assessments in VKH disease. Moreover, it has the potential to reduce the need for retinal angiography.

Key messages: What is known Optical coherence tomography (OCT) and indocyanine green angiography (ICGA) are essential for the diagnosis of Vogt-Koyanagi-Harada (VKH) disease. However, it is difficult to visualize a wide area of the fundus with OCT, and ICGA carries risks of allergic reactions or shock. What is new Retromode infrared scanning laser ophthalmoscopy (RMI-SLO) can demonstrate pseudo-three-dimensional regions and wavy patterns corresponding to serous retinal detachment and choroidal folds in the acute stage of VKH disease. Hyper-reflective choroidal vasculature was absent in the acute stage of VKH disease on RMI-SLO and may correlate with choroidal thickening. RMI-SLO could be an alternative option for the assessment of VKH disease and has the potential to reduce the need for dye-based retinal angiography.

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Vogt-Koyanagi-Harada 病的 Retromode 红外线扫描激光眼底镜检查。

目的：本研究使用反色法红外扫描激光眼底镜（RMI-SLO）检查了六名Vogt-Koyanagi-Harada（VKH）疾病患者：我们对六名确诊为 VKH 疾病患者的病历进行了单中心回顾性审查。将 RMI-SLO 图像与使用彩色眼底照相术、光学相干断层扫描（OCT）和染料视网膜血管造影术获得的图像进行比较：结果：在 VKH 病变的急性期，RMI-SLO 显示了假三维（3D）区域和波浪形图案。这些观察结果与 OCT 上发现的浆液性视网膜脱离（sRD）区域和脉络膜皱褶相对应。值得注意的是，在识别sRD方面，RMI-SLO对伪三维区域的检测比彩色眼底照相更有效。在 RMI-SLO 图像中可以观察到 sRD 内部的高反射线，与 OCT 图像中观察到的纤维膜一致。RMI-SLO 图像中的高反射脉络膜血管明显缺失，这一发现与吲哚青绿血管造影图像中观察到的基质脉络膜大血管模糊模式相似。经过类固醇治疗后，这些异常发现恢复了正常：RMI-SLO成像可作为VKH疾病治疗前和治疗后评估的替代选择。此外，它还有可能减少对视网膜血管造影的需求：已知信息光学相干断层扫描（OCT）和吲哚青绿血管造影术（ICGA）是诊断 Vogt-Koyanagi-Harada (VKH) 病的基本方法。然而，用 OCT 很难观察到大面积的眼底，而 ICGA 则存在过敏反应或休克的风险。新技术 Retromode 红外扫描激光眼底镜（RMI-SLO）可显示出与 VKH 急性期浆液性视网膜脱离和脉络膜皱褶相对应的假三维区域和波浪形图案。在 RMI-SLO 上，VKH 急性期的脉络膜血管没有高反射，可能与脉络膜增厚有关。RMI-SLO 可以作为评估 VKH 疾病的另一种选择，并有可能减少对基于染料的视网膜血管造影的需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.