Skin sensitisation elicitation: Evaluation of the general threshold and considerations for use

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-11-24 DOI:10.1111/cod.14718

Brian Palmer, Yuan Gao, Cindy Ryan, Petra Kern

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引用次数: 0

Abstract

Background

Allergic contact dermatitis (ACD) is an immune response to chemical haptens, involving induction and elicitation phases. Quantitative risk assessment (QRA) reviewing the skin sensitisation potential for all ingredients and using chemical-specific induction thresholds for skin allergens remains the current best approach for the safety evaluation of consumer products. However, elicitation thresholds have utility in secondary protection for pre-sensitised consumers.

Objectives

The objectives were to (1) review the current elicitation threshold database, (2) evaluate whether predicted relationships between chemical induction and elicitation potencies enable elicitation threshold prediction and (3) discuss elicitation threshold utility as a secondary method of consumer protection.

Methods

In total, 28 publications (with 39 elicitation datasets) were included in non-linear regression analysis to derive elicitation thresholds for 22 allergens, including fragrances, preservatives and metals.

Results

The median elicitation threshold (ED₁₀) for the expanded database was 0.95 μg/cm², which supports previously published general elicitation thresholds. The derived ED₁₀ for each chemical had only weak to moderate correlation with corresponding induction thresholds, thus limiting suitability as the predictive model.

Conclusions

Assessment of current EU fragrance allergen labelling and sensitiser labelling under the globally harmonised system in the context of general and chemical-specific elicitation thresholds shows that current practices are health protective.

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皮肤过敏激发：一般阈值评估和使用注意事项。

背景：过敏性接触性皮炎 (ACD) 是一种对化学过敏原的免疫反应，包括诱导和激发两个阶段。定量风险评估（QRA）对所有成分的皮肤致敏可能性进行审查，并对皮肤过敏原使用特定化学诱导阈值，这仍然是目前消费品安全评估的最佳方法。不过，诱导阈值在为预先过敏的消费者提供二级保护方面具有实用性：目的是：(1) 回顾当前的激发阈值数据库；(2) 评估化学诱导和激发效力之间的预测关系是否有助于激发阈值预测；(3) 讨论激发阈值作为消费者保护二级方法的效用：非线性回归分析共纳入了 28 篇出版物（39 个诱发数据集），以得出 22 种过敏原（包括香料、防腐剂和金属）的诱发阈值：扩展数据库的中位激发阈值（ED10）为 0.95 μg/cm2，这与之前公布的一般激发阈值一致。得出的每种化学物质的 ED10 与相应的诱发阈值只有微弱到中等程度的相关性，因此限制了作为预测模型的适用性：根据一般和特定化学物质的诱发阈值，对目前欧盟香料过敏原标签和全球统一系统下的致敏剂标签进行的评估表明，目前的做法对健康是有保护作用的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".