Highly Conjugated Ergosterols with Anti-Influenza Virus Activity from the Marine-Derived Fungus Eutypella sp. F0219.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2024-11-24 DOI:10.1002/cbdv.202402465

Zhongping Jiang, Meng-Ting Chen, Han-Yu Chen, Yan-Fang Luo, Jing Zhou, Jing-Jing Yang, Zhong-Ping Jiang, Ling Huang

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引用次数: 0

Abstract

one rare 15-nor-cadinane sesquiterpenoid (1), one new chromene amide derivative (2), and one new highly conjugated ergosterol steroid (3), along with three known compounds (4-6) were isolated from the marine-derived fungus Eutypella sp. F0219. Their chemical structures including absolute configurations were established by HR-ESIMS, extensive 1D and 2D NMR investigations, and electronic circular dichroism (ECD) calculations. All compounds were evaluated for their anti-influenza A virus and anti-influenza B virus activities against the A/PR/8/34 (H1N1), ZX1109 (H1N1, oseltamivir resistant virus), HK68 (H3N2), and B/Florida/78/2015 strains. Compounds 3 and 4 showed significant antiviral activities against those four virus strains with EC50 values ranging from 2.07 to 11.3 μM. Most notably, compound 3 exhibited potent anti-influenza B virus activity against B/Florida/78/2015 strain with EC50 value of 2.27±1.76 μM, versus the postive control (oseltamivir, EC50 = 7.14±1.94 μM).

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具有抗流感病毒活性的海洋真菌 Eutypella sp.

从海洋真菌 Eutypella sp. F0219 中分离出了一种罕见的 15-nor-cadinane 倍半萜类化合物（1）、一种新的色烯酰胺衍生物（2）和一种新的高度共轭麦角甾醇类化合物（3）以及三种已知化合物（4-6）。通过 HR-ESIMS、广泛的一维和二维核磁共振研究以及电子圆二色性（ECD）计算，确定了它们的化学结构（包括绝对构型）。评估了所有化合物对 A/PR/8/34 (H1N1)、ZX1109 (H1N1，奥司他韦耐药病毒)、HK68 (H3N2) 和 B/Florida/78/2015 株的抗甲型流感病毒和抗乙型流感病毒活性。化合物 3 和 4 对这四种病毒株具有显著的抗病毒活性，其 EC50 值介于 2.07 到 11.3 μM 之间。最值得注意的是，化合物 3 对 B/Florida/78/2015 株显示出强大的抗乙型流感病毒活性，EC50 值为 2.27±1.76 μM，而阳性对照（奥司他韦，EC50 = 7.14±1.94 μM）为 2.27±1.76 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.