Comparison of clinical characteristics, risk factors, and outcomes of patients infected with Bacteroides fragilis group at a tertiary care hospital in central China between 2017 and March 2024

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2024-11-22 DOI:10.1016/j.anaerobe.2024.102922

Yongmei Li , Jing Zhao , Qiong Ma , Junhong Xu , Youhua Yuan , Qi Zhang , Wenjuan Yan , Wenbo Xu , Zhiyu Yang , Gang Li , Lan Gao , Baoya Wang

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Abstract

Objectives

This study aimed to explore the epidemiology, clinical presentation, and risk factors for treatment failure in patients infected with various Bacteroides fragilis group (BFG) species.

Methods

We analyzed clinical and laboratory data from 178 patients infected with BFG who were admitted to our hospital between 2017 and 2024. We analyzed categorical data using Chi-square and Fisher exact tests, continuous variables using Student's t-tests or Mann–Whitney U-tests, and risk factors using multivariate logistic regression and Pearson's chi-squared tests.

Results

Bacteroides fragilis (69.7 %) and Bacteroides thetaiotaomicron (16.9 %) were the most prevalent species among 178 BFG isolates. Most patients had polymicrobial infections, with the following pathogens isolated from concurrent samples: Escherichia coli, Klebsiella spp., and Enterococcus spp. Intra-abdominal sites were most frequently infected with BFG. Patients aged >50 years and those who had intravascular catheters were infected with more other Bacteroides species than B. fragilis. Admission to an ICU, respiratory, renal and cardiovascular diseases, and chest drainage were associated more often with B. thetaiotaomicron than with B. fragilis. Gastrointestinal diseases, tracheal intubation, and ICU admission were associated more frequently with treatment failure in patients infected with B. fragilis whereas solid cancers, renal disease, multiple organ dysfunction syndrome, and tracheal intubation were more likely to be associated with treatment failure in patients infected with other Bacteroides spp.

Conclusions

The most prevalent BFG species in the patients were B. fragilis and B. thetaiotaomicron. The demographic characteristics of the patients, underlying diseases, and risk factors for poor clinical outcomes clearly differed among species.

查看原文本刊更多论文

2017年至2024年3月华中某三甲医院易碎杆菌组感染患者的临床特征、风险因素和预后比较。

研究目的本研究旨在探讨各种脆弱拟杆菌属（BFG）感染患者的流行病学、临床表现和治疗失败的风险因素：我们分析了2017年至2024年间本院收治的178名BFG感染者的临床和实验室数据。我们使用卡方检验（Chi-square）和费雪精确检验（Fisher exact）对分类数据进行分析，使用学生 t 检验或曼惠尼 U 检验对连续变量进行分析，使用多变量逻辑回归和皮尔逊卡方检验对风险因素进行分析：结果：在178个BFG分离株中，最常见的菌种是脆弱拟杆菌（69.7%）和泰奥米克隆拟杆菌（16.9%）。大多数患者有多微生物感染，同时从样本中分离出以下病原体：腹腔部位最常感染 BFG。年龄大于 50 岁的患者和使用血管内导管的患者感染的其他乳杆菌要多于脆弱拟杆菌。与脆弱拟杆菌相比，入住重症监护室、患有呼吸系统、肾脏和心血管疾病以及胸腔引流的患者更常感染泰氏菌。胃肠道疾病、气管插管和入住重症监护室与感染脆弱拟杆菌的患者治疗失败的相关性更高，而实体瘤、肾脏疾病、多器官功能障碍综合征和气管插管与感染其他乳杆菌属的患者治疗失败的相关性更高：结论：患者中最常见的乳糜泻菌为脆弱拟杆菌（B. fragilis）和大肠杆菌（B. thetaiotaomicron）。不同菌种的患者人口统计学特征、基础疾病和临床疗效不佳的风险因素明显不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.