Ampicillin-derived carbon dots as the sensitive probe for the detection of Fe3+ and Cu2+ in living cells and water samples

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2024-11-25 DOI:10.1007/s00604-024-06849-5

Hongjie Dong, Huanhuan Xie, Xiaoman Xie, Qi Wang, Hang Sun, Wenju Zhu, Guihua Zhao, Chao Xu, Kun Yin, Junmei Zhang

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引用次数: 0

Abstract

Water-soluble N-doped fluorescent (FL) carbon dots (ACDs) were successfully fabricated hydrothermally using ampicillin sodium as sole precursor. The produced ACDs exhibit satisfactory optical behavior, favorable photostability, and acceptable water solubility. With bright blue emission at 450 nm, the ACDs were utilized for multivariate sensing Fe³⁺ and Cu²⁺ based on the synergistic effect of the inner filter effect (IFE) and static quenching with detection limits of 0.31 μM and 0.26 μM, respectively. The practicality of ACDs has been verified by the successful determination of Fe³⁺ and Cu²⁺ in real water and living cells. These findings confirm the feasibility of the proposed ACDs as FL sensors for efficient and selective detection of Fe³⁺ and Cu²⁺, which present promising prospects for real-time monitoring these two metal ions in environmental and biological systems.

Graphical Abstract

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氨苄青霉素衍生碳点是检测活细胞和水样中 Fe3+ 和 Cu2+ 的灵敏探针。

以氨苄西林钠为唯一前驱体，通过水热法成功制备了水溶性 N 掺杂荧光（FL）碳点（ACDs）。制得的 ACD 具有令人满意的光学特性、良好的光稳定性和可接受的水溶性。ACD 在 450 纳米波长处发出明亮的蓝光，基于内滤光片效应（IFE）和静态淬灭的协同效应，ACD 可用于检测 Fe3+ 和 Cu2+，检测限分别为 0.31 μM 和 0.26 μM。ACD 的实用性已通过成功测定真实水中和活细胞中的 Fe3+ 和 Cu2+ 得到验证。这些研究结果证实了所提出的 ACDs 作为 FL 传感器高效、选择性地检测 Fe3+ 和 Cu2+ 的可行性，为实时监测环境和生物系统中的这两种金属离子带来了广阔的前景。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.