Construction of strontium-loaded injectable lubricating hydrogel and its role in promoting repair of cartilage defects.

IF 5.8 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Congcong Duan, Hongyue Jiang, Shichen Zhang, Yixing Wang, Peng Liu, Bin Xu, Wenjing Tian, Bing Han
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引用次数: 0

Abstract

Injuries such as articular cartilage defects are prevalent factors in the development and progression of joint diseases. The discontinuity of the articular surface due to cartilage defects significantly accelerates the onset of arthritis. Cartilage tissue-engineered scaffolds are essential for restoring the continuity of the articular surface. This study presents a dual-network hydrogel, GelMA-FT/Sr2+, which demonstrates excellent lubrication properties and accelerates the healing of cartilage defects. The hydrogel is composed of a methacrylated gelatin (GelMA) network, an N-fluorenylmethoxycarbonyl-L-tryptophan (FT) network, and strontium ions (Sr2+). The results indicate that the hydrogel exhibits lubricating properties, and the incorporation of Sr2+ extends the degradation time of the hydrogel. Additionally, the hydrogel shows biocompatibility and enhances chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into cartilage. In vivo studies further confirm the hydrogel's efficacy in promoting the repair of cartilage defects in a rat model of cartilage injury. In conclusion, the GelMA-FT/Sr2+ hydrogel is a promising scaffold for cartilage tissue engineering, notable for its excellent lubrication properties, ability to recruit stem cells, and effectiveness in facilitating cartilage defect repair.

锶负载注射润滑水凝胶的构建及其在促进软骨缺损修复中的作用。
关节软骨缺损等损伤是关节疾病发生和发展的常见因素。软骨缺损导致的关节表面不连续会大大加速关节炎的发病。软骨组织工程支架对于恢复关节表面的连续性至关重要。本研究介绍了一种双网络水凝胶 GelMA-FT/Sr2+,它具有出色的润滑性能,能加速软骨缺损的愈合。该水凝胶由甲基丙烯酸明胶(GelMA)网络、N-芴甲氧羰基-L-色氨酸(FT)网络和锶离子(Sr2+)组成。结果表明,水凝胶具有润滑性能,Sr2+ 的加入延长了水凝胶的降解时间。此外,水凝胶还具有生物相容性,并能促进骨髓间充质干细胞向软骨的软骨分化。体内研究进一步证实了水凝胶在大鼠软骨损伤模型中促进软骨缺损修复的功效。总之,GelMA-FT/Sr2+水凝胶是一种用于软骨组织工程的前景广阔的支架,它具有出色的润滑性能、招募干细胞的能力以及促进软骨缺损修复的功效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomaterials Science
Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.50%
发文量
556
期刊介绍: Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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