Association Between Polycystic Ovary Syndrome and Pancreatic Cancer in a Retrospective Case-Control Study

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2024-11-25 DOI:10.1155/ijcp/9066933

Pei-Ying Chung, Kuan-Fu Liao, Yu-Hung Kuo, Shih-Wei Lai

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Abstract

Objective: To assess the association between polycystic ovary syndrome and pancreatic cancer in Taiwan.

Methods: We used the 2013–2020 claims data of Taiwan National Health Insurance Program. A case-control study was performed, including female subjects 20 years or older with and without pancreatic cancer. Cases comprised female subjects diagnosed with pancreatic cancer, identified based on diagnosis codes. Controls were selected from female subjects without pancreatic cancer and matched to cases on age and comorbidities. Polycystic ovary syndrome was identified through diagnosis codes. A conditional logistic regression model was used to assess the association between polycystic ovary syndrome and pancreatic cancer, with results presented as odds ratio (OR) and 95% confidence interval (CI).

Results: This case-control study included 12,466 cases with pancreatic cancer and 49,864 matched controls. The proportions of polycystic ovary syndrome were 2.6% among cases with pancreatic cancer and 1.4% among controls without pancreatic cancer (p < 0.001). After controlling for confounding factors, the conditional logistical regression model revealed a statistically significant association between polycystic ovary syndrome and pancreatic cancer, with an OR of 1.38 (95% CI = 1.21–1.59, p < 0.001).

Conclusion: This case-control study reveals that there is a statistically significant association between polycystic ovary syndrome and pancreatic cancer. More studies are needed to provide robust evidence.

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一项回顾性病例对照研究中多囊卵巢综合征与胰腺癌之间的关系

目的评估台湾多囊卵巢综合征与胰腺癌之间的关系。方法我们使用了台湾国民健康保险计划 2013-2020 年的理赔数据。我们进行了一项病例对照研究，研究对象包括 20 岁及以上患有和未患有胰腺癌的女性受试者。病例包括根据诊断代码确诊为胰腺癌的女性受试者。对照组从未患过胰腺癌的女性受试者中选取，在年龄和合并症方面与病例相匹配。多囊卵巢综合征通过诊断代码确定。采用条件逻辑回归模型评估多囊卵巢综合征与胰腺癌之间的关系，结果以几率比（OR）和 95% 置信区间（CI）表示。研究结果这项病例对照研究包括 12,466 例胰腺癌病例和 49,864 例匹配对照。在胰腺癌病例中，多囊卵巢综合征的比例为 2.6%，而在未患胰腺癌的对照组中，多囊卵巢综合征的比例为 1.4%（p <0.001）。在控制了混杂因素后，条件统计回归模型显示多囊卵巢综合征与胰腺癌之间存在显著的统计学关联，OR 值为 1.38（95% CI = 1.21-1.59，p <0.001）。结论这项病例对照研究显示，多囊卵巢综合征与胰腺癌之间存在统计学意义上的显著关联。需要更多的研究来提供可靠的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.