The Evaluation of the Relationship Between Coronary Ectasia and Trimethylamine N-Oxide

IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Hasan Sari, Yakup Alsancak, Ahmet Seyfeddin Gurbuz, Oznur Keskin, Sefa Tatar, Mehmet Akif Duzenli
{"title":"The Evaluation of the Relationship Between Coronary Ectasia and Trimethylamine N-Oxide","authors":"Hasan Sari,&nbsp;Yakup Alsancak,&nbsp;Ahmet Seyfeddin Gurbuz,&nbsp;Oznur Keskin,&nbsp;Sefa Tatar,&nbsp;Mehmet Akif Duzenli","doi":"10.1155/ijcp/7356380","DOIUrl":null,"url":null,"abstract":"<div>\n <p><b>Introduction:</b> It is now known that the microbiota is far beyond the microbial communities living in certain parts of our body and functions like a metabolic organ. In addition, the microbiota, through its metabolites, is involved in the pathophysiology or progression of a wide range of diseases, from atherosclerotic diseases to metabolic diseases and even neurological diseases. Among these metabolites, trimethylamine n-oxide metabolite has been shown to be particularly effective in atherosclerotic heart diseases.</p>\n <p><b>Materials and Methods:</b> A total of 155 patients, who underwent coroner angiography for stable angina were included in the study. Of these patients, 81 patients with coronary artery ectasia (patient group) and 74 patients without coronary artery ectasia (control group) were evaluated for trimethylamine n-oxide metabolite.</p>\n <p><b>Results:</b> Statistically significantly higher trimethylamine n-oxide metabolite levels were observed in the coronary artery ectasia group compared to the control group.</p>\n <p><b>Conclusion:</b> The significantly higher trimethylamine n-oxide levels in patients with coronary artery ectasia without coronary artery disease suggest that the microbiota and its metabolites independently play a role in the pathophysiology or progression of vascular remodeling or endothelial dysfunctions. Also, its effect on the endothelial surface may depend on the threshold value.</p>\n </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7356380","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/ijcp/7356380","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: It is now known that the microbiota is far beyond the microbial communities living in certain parts of our body and functions like a metabolic organ. In addition, the microbiota, through its metabolites, is involved in the pathophysiology or progression of a wide range of diseases, from atherosclerotic diseases to metabolic diseases and even neurological diseases. Among these metabolites, trimethylamine n-oxide metabolite has been shown to be particularly effective in atherosclerotic heart diseases.

Materials and Methods: A total of 155 patients, who underwent coroner angiography for stable angina were included in the study. Of these patients, 81 patients with coronary artery ectasia (patient group) and 74 patients without coronary artery ectasia (control group) were evaluated for trimethylamine n-oxide metabolite.

Results: Statistically significantly higher trimethylamine n-oxide metabolite levels were observed in the coronary artery ectasia group compared to the control group.

Conclusion: The significantly higher trimethylamine n-oxide levels in patients with coronary artery ectasia without coronary artery disease suggest that the microbiota and its metabolites independently play a role in the pathophysiology or progression of vascular remodeling or endothelial dysfunctions. Also, its effect on the endothelial surface may depend on the threshold value.

Abstract Image

评估冠状动脉栓塞与三甲胺氧化物之间的关系
简介现在人们已经知道,微生物群远远超出了生活在我们身体某些部位的微生物群落,其功能就像一个新陈代谢器官。此外,微生物群通过其代谢物参与了从动脉粥样硬化疾病到代谢性疾病甚至神经系统疾病等多种疾病的病理生理学或进展过程。在这些代谢物中,三甲胺正氧化物代谢物已被证明对动脉粥样硬化性心脏病特别有效。 材料和方法:研究共纳入 155 名因稳定型心绞痛接受冠状动脉造影术的患者。对其中 81 名冠状动脉异位患者(患者组)和 74 名无冠状动脉异位患者(对照组)进行了三甲胺正氧化物代谢物评估。 结果显示与对照组相比,冠状动脉异位组的三甲胺正氧化物代谢物水平明显更高。 结论无冠状动脉疾病的冠状动脉异位患者的三甲胺正氧化物水平明显较高,这表明微生物群及其代谢物在血管重塑或内皮功能障碍的病理生理或进展过程中独立发挥作用。此外,其对内皮表面的影响可能取决于阈值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.30
自引率
0.00%
发文量
274
审稿时长
3-8 weeks
期刊介绍: IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信