The curvature-adaptive voxel Monte Carlo (CAVMC) method-based photothermal model for customized retinal laser surgery

IF 4.9 2区工程技术 Q1 ENGINEERING, MECHANICAL

International Journal of Thermal Sciences Pub Date : 2024-11-24 DOI:10.1016/j.ijthermalsci.2024.109572

Hao Zhang , Dong Li , Bin Chen , Hanfeng Zhang , Liang Yao , Yuping Zheng , Guoxiang Wang

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引用次数: 0

Abstract

Laser photothermal therapy is widely used in ophthalmology to treat retinal diseases such as diabetic retinopathy and age-related macular degeneration. Precise control of laser energy absorbed by the retinal pigment epithelium (RPE) and blood vessels is crucial to avoid insufficient or excessive treatment. To overcome the limitations of traditional Monte Carlo (MC) methods including Voxel-based (VMC) and Tetrahedral-based (TMC) MC, a new Curvature-Adaptive Voxel-based Monte Carlo (CAVMC) method is proposed. The CAVMC introduces artificial surfaces aligned with curved interfaces to improve the accuracy of light transport simulations, thereby achieving near-perfect agreement with TMC results while reducing computational costs by 70 %. Simulations of various retinal laser treatment protocols, including Panretinal Photocoagulation (PRP), Transpupillary Thermotherapy (TTT), Micropulse Laser Therapy (MLT), and Selective Retina Therapy (SRT), demonstrated that CAVMC reduces thermal prediction errors by up to 25 % compared to VMC. This method offers a powerful tool for optimizing retinal laser surgery, balancing high accuracy with computational efficiency, and holds promise for broader biomedical applications.

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基于曲率自适应体素蒙特卡洛（CAVMC）方法的光热模型，用于定制视网膜激光手术

激光光热疗法被广泛应用于眼科治疗糖尿病视网膜病变和老年性黄斑变性等视网膜疾病。精确控制视网膜色素上皮（RPE）和血管吸收的激光能量对于避免治疗不足或治疗过度至关重要。为了克服传统蒙特卡洛（Monte Carlo，MC）方法（包括基于体素（Voxel-based，VMC）和基于四面体（Tetrahedral-based，TMC）的 MC）的局限性，我们提出了一种新的基于体素的曲率自适应蒙特卡洛（Curvature-Adaptive Voxel-based Monte Carlo，CAVMC）方法。CAVMC 引入了与弯曲界面对齐的人工表面，以提高光传输模拟的准确性，从而实现与 TMC 结果近乎完美的一致，同时将计算成本降低了 70%。对各种视网膜激光治疗方案（包括全视网膜光凝（PRP）、经瞳孔热疗（TTT）、微脉冲激光治疗（MLT）和选择性视网膜治疗（SRT））的模拟表明，与 VMC 相比，CAVMC 最多可减少 25% 的热预测误差。这种方法为优化视网膜激光手术提供了强大的工具，兼顾了高精度和计算效率，有望在生物医学领域得到更广泛的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Thermal Sciences 工程技术-工程：机械

CiteScore

8.10

自引率

11.10%

发文量

531

审稿时长

55 days

期刊介绍： The International Journal of Thermal Sciences is a journal devoted to the publication of fundamental studies on the physics of transfer processes in general, with an emphasis on thermal aspects and also applied research on various processes, energy systems and the environment. Articles are published in English and French, and are subject to peer review. The fundamental subjects considered within the scope of the journal are: * Heat and relevant mass transfer at all scales (nano, micro and macro) and in all types of material (heterogeneous, composites, biological,...) and fluid flow * Forced, natural or mixed convection in reactive or non-reactive media * Single or multi–phase fluid flow with or without phase change * Near–and far–field radiative heat transfer * Combined modes of heat transfer in complex systems (for example, plasmas, biological, geological,...) * Multiscale modelling The applied research topics include: * Heat exchangers, heat pipes, cooling processes * Transport phenomena taking place in industrial processes (chemical, food and agricultural, metallurgical, space and aeronautical, automobile industries) * Nano–and micro–technology for energy, space, biosystems and devices * Heat transport analysis in advanced systems * Impact of energy–related processes on environment, and emerging energy systems The study of thermophysical properties of materials and fluids, thermal measurement techniques, inverse methods, and the developments of experimental methods are within the scope of the International Journal of Thermal Sciences which also covers the modelling, and numerical methods applied to thermal transfer.