Polysaccharide-based hydrogels for atopic dermatitis management: A review

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED
Harinash Rao, Joash Ban Lee Tan
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Abstract

Atopic dermatitis (AD) is the most common form of eczema and the most burdensome skin disease globally, affecting nearly 223 million. A major AD predisposition is genetic susceptibility, affecting skin barrier integrity and cell-mediated immunity. Manifesting as red, dry, and itchy skin, basic treatment involves skin hydration with emollients. Despite their effectiveness, poor patient compliance remains a major drawback. In severe cases, medicated emollients are used, but carry risks, including skin thinning, and immunosuppression. Hence, hydrogels have emerged as a promising alternative for AD management based on their ability to improve skin hydration, attributed to their hydrophilicity and high water retention capacity. Moreover, researchers have loaded hydrogels with various compounds for AD management; they also hold the potential to reduce systemic side effects of commercial drugs by enhancing dermal retention. Hydrogels address the challenges of patient compliance based on their non-greasy texture and reduced application frequency. Their appeal also stems from their versatility, as they can be fabricated from varying polymers. Due to their abundance, this review focuses on polysaccharides including alginate, cellulose, chitosan, and hyaluronic acid, which are preferred for fabricating natural and modified natural hydrogels for AD. It also briefly explores hydrogel application methods and key AD models.

Abstract Image

多糖类水凝胶治疗特应性皮炎:综述
特应性皮炎(AD)是湿疹中最常见的一种,也是全球负担最重的皮肤病,患病人数接近 2.23 亿。特应性皮炎的一个主要诱因是遗传易感性,它会影响皮肤屏障的完整性和细胞介导的免疫力。瘙痒症表现为皮肤发红、干燥和瘙痒,基本治疗方法包括使用润肤剂为皮肤补充水分。尽管润肤剂效果显著,但患者依从性差仍是一大弊端。在严重病例中,可使用药物润肤剂,但存在皮肤变薄和免疫抑制等风险。因此,水凝胶因其亲水性和高保水能力,能够改善皮肤水合状态,已成为治疗急性溃疡的一种有前途的替代品。此外,研究人员还在水凝胶中添加了各种化合物,用于治疗注意力缺失症;水凝胶还可以通过增强皮肤保留力来减少商业药物的全身副作用。水凝胶质地不油腻,减少了涂抹次数,解决了患者依从性方面的难题。水凝胶的吸引力还来自于它的多功能性,因为它可以由不同的聚合物制成。由于多糖种类繁多,本综述将重点讨论海藻酸、纤维素、壳聚糖和透明质酸等多糖,这些多糖是制造用于 AD 的天然和改性天然水凝胶的首选材料。本综述还简要探讨了水凝胶的应用方法和主要的 AD 模型。
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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