Trends in incidence and survival of the four most common cancers by stage at diagnosis in Cyprus: A population-based study from 2004 to 2017

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2024-11-23 DOI:10.1016/j.canep.2024.102704

Christiana A. Demetriou , Constantinos Koshiaris , Olivia A. Cory , Constantina Constantinou , Ourania Kolokotroni , Yiola Marcou , Demetris Papamichael , Haris Charalambous , Dimitrios Vomvas , Anna Demetriou , Vasos Scoutellas , Annalisa Quattrocchi

{"title":"Trends in incidence and survival of the four most common cancers by stage at diagnosis in Cyprus: A population-based study from 2004 to 2017","authors":"Christiana A. Demetriou , Constantinos Koshiaris , Olivia A. Cory , Constantina Constantinou , Ourania Kolokotroni , Yiola Marcou , Demetris Papamichael , Haris Charalambous , Dimitrios Vomvas , Anna Demetriou , Vasos Scoutellas , Annalisa Quattrocchi","doi":"10.1016/j.canep.2024.102704","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Breast, colorectal, lung and prostate cancers are the most frequent malignancies in Cyprus. This study estimated the incidence rate and 5-year net survival (NS) trends for these cancers, by sex, age, and tumor stage at diagnosis.</div></div><div><h3>Methods</h3><div>We analyzed data from the Cyprus Cancer Registry for adults diagnosed between 2004 and 2017, with follow-up until 2019. Tumor stage was classified into localized, regional, distant and unknown categories. We estimated the annual percentage change (APC) in incidence rates using Joinpoint regression. NS was estimated using flexible parametric models, adjusting for sex, age, stage and period of diagnosis. Multiple imputation was used to address unknown cancer stage.</div></div><div><h3>Results</h3><div>During 2004–2017, the incidence significantly increased for breast and lung cancer (APC: 1.1 % and 2.6 %, respectively), mainly among the elderly (70 +). A decreasing trend was identified for prostate cancer only among individuals aged 80 +. No temporal variations were identified for colorectal cancer incidence.</div><div>A positive time trend was identified for localized breast cancer between 2006 and 2017 (APC: 2.8 %). Conversely, a significant increase was noted at more advanced stages for lung (APC<sub>distant</sub>: 4.1 %) and prostate (APC<sub>regional</sub>: 7.6 %) cancers.</div><div>NS improved for all cancers, ranging between 80 % and 90 % for regional and all stages of breast cancer, localized colorectal cancer, and all stages of prostate cancer, surpassing 95 % for localized breast cancer, localized and regional prostate cancer.</div></div><div><h3>Conclusion</h3><div>The study observed increased (breast and lung) or stable (colorectal and prostate) cancer incidence and substantial improvements in 5-years NS trends for all cancer types, despite differences by sex and stage. Efforts should be intensified to reduce incidence by addressing cancer risk factors, and to improve survival by implementing and increasing the uptake of screening programs.</div></div>","PeriodicalId":56322,"journal":{"name":"Cancer Epidemiology","volume":"94 ","pages":"Article 102704"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Epidemiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877782124001838","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Breast, colorectal, lung and prostate cancers are the most frequent malignancies in Cyprus. This study estimated the incidence rate and 5-year net survival (NS) trends for these cancers, by sex, age, and tumor stage at diagnosis.

Methods

We analyzed data from the Cyprus Cancer Registry for adults diagnosed between 2004 and 2017, with follow-up until 2019. Tumor stage was classified into localized, regional, distant and unknown categories. We estimated the annual percentage change (APC) in incidence rates using Joinpoint regression. NS was estimated using flexible parametric models, adjusting for sex, age, stage and period of diagnosis. Multiple imputation was used to address unknown cancer stage.

Results

During 2004–2017, the incidence significantly increased for breast and lung cancer (APC: 1.1 % and 2.6 %, respectively), mainly among the elderly (70 +). A decreasing trend was identified for prostate cancer only among individuals aged 80 +. No temporal variations were identified for colorectal cancer incidence.

A positive time trend was identified for localized breast cancer between 2006 and 2017 (APC: 2.8 %). Conversely, a significant increase was noted at more advanced stages for lung (APC_distant: 4.1 %) and prostate (APC_regional: 7.6 %) cancers.

NS improved for all cancers, ranging between 80 % and 90 % for regional and all stages of breast cancer, localized colorectal cancer, and all stages of prostate cancer, surpassing 95 % for localized breast cancer, localized and regional prostate cancer.

Conclusion

The study observed increased (breast and lung) or stable (colorectal and prostate) cancer incidence and substantial improvements in 5-years NS trends for all cancer types, despite differences by sex and stage. Efforts should be intensified to reduce incidence by addressing cancer risk factors, and to improve survival by implementing and increasing the uptake of screening programs.

查看原文本刊更多论文

塞浦路斯按诊断阶段划分的四种最常见癌症的发病率和生存率趋势：2004 年至 2017 年基于人口的研究

背景乳腺癌、结直肠癌、肺癌和前列腺癌是塞浦路斯最常见的恶性肿瘤。这项研究按性别、年龄和诊断时的肿瘤分期估算了这些癌症的发病率和 5 年净生存率（NS）趋势。肿瘤分期分为局部、区域、远处和未知类别。我们使用Joinpoint回归估算了发病率的年度百分比变化（APC）。NS采用灵活的参数模型进行估算，并根据性别、年龄、分期和诊断时间进行调整。结果2004-2017年间，乳腺癌和肺癌的发病率显著上升（APC：分别为1.1%和2.6%），主要发生在老年人（70岁以上）中。只有在 80 岁以上的人群中，前列腺癌的发病率呈下降趋势。2006 年至 2017 年间，局部乳腺癌的发病率呈上升趋势（APC：2.8%）。所有癌症的 NS 均有所改善，区域性和所有阶段的乳腺癌、局部性结直肠癌以及所有阶段的前列腺癌的 NS 在 80% 至 90% 之间，局部性乳腺癌、局部性和区域性前列腺癌的 NS 超过 95%。结论该研究观察到，尽管性别和分期不同，但所有癌症类型的发病率（乳腺癌和肺癌）均有所上升或保持稳定（结肠直肠癌和前列腺癌），5 年 NS 趋势也有显著改善。应加强努力，通过应对癌症风险因素来降低发病率，并通过实施筛查计划和提高筛查率来提高生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.