High-performance electrochemical detection for trace minocycline based on boron-doped-diamond/carbon nanowalls biosensor

IF 10.5 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Carbon Pub Date : 2024-11-19 DOI:10.1016/j.carbon.2024.119835

Linfeng Wan , Yaqi Liang , Mingchao Yang , Qiuxia Zhang , Siyu Xu , Shaoheng Cheng , Nan Gao , Danhong Zhang , Yibo Ma

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Abstract

Highly sensitive electrochemical detection of trace minocycline (MCL), one of the most important antibiotics, presents a challenge due to the lack of suitable substrates and low detection efficiency. In this work, an electrochemical biosensor with an electrode consisting of boron-doped diamond (BDD) and carbon nanowalls (CNWs) (named BDD/CNWs) is designed for the detection of MCL. The electrochemical behavior of MCL at varying scan rates suggests an adsorption-controlled mechanism dominating the process on the BDD/CNWs electrode. The sensor demonstrates good linearity in the range from 0.02 to 100 μM and achieved a limit of detection as low as 9.8 nM, ascribed to the synergistic effect of the combination of BDD with CNWs, which provide a broad potential window (2.63 V), more reaction sites, and low charge transfer resistance (87 Ω) from the electrode. Examinations of trace MCL in citric acid-phosphate buffer, tap water, rat blood, as well as interference tests, reveal high sensitivity, specificity, stability, and repeatability of the BDD/CNWs electrode, which shows promise for practical applications.

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基于掺硼金刚石/碳纳米墙生物传感器的痕量米诺环素高性能电化学检测技术

高灵敏度电化学检测痕量米诺环素（MCL）是最重要的抗生素之一，但由于缺乏合适的基底和检测效率低，该检测方法面临挑战。本研究设计了一种由掺硼金刚石（BDD）和碳纳米墙（CNWs）（命名为 BDD/CNWs）组成电极的电化学生物传感器，用于检测 MCL。MCL 在不同扫描速率下的电化学行为表明，BDD/CNWs 电极上的吸附控制机制主导了这一过程。该传感器在 0.02 至 100 μM 范围内表现出良好的线性，检测限低至 9.8 nM，这归功于 BDD 与 CNWs 组合的协同效应，它们提供了一个宽电位窗口（2.63 V）、更多的反应位点以及电极的低电荷转移电阻（87 Ω）。对柠檬酸-磷酸盐缓冲液、自来水、大鼠血液中痕量 MCL 的检测以及干扰测试表明，BDD/CNWs 电极具有高灵敏度、特异性、稳定性和可重复性，有望得到实际应用。

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来源期刊

Carbon 工程技术-材料科学：综合

CiteScore

20.80

自引率

7.30%

发文量

审稿时长

23 days

期刊介绍： The journal Carbon is an international multidisciplinary forum for communicating scientific advances in the field of carbon materials. It reports new findings related to the formation, structure, properties, behaviors, and technological applications of carbons. Carbons are a broad class of ordered or disordered solid phases composed primarily of elemental carbon, including but not limited to carbon black, carbon fibers and filaments, carbon nanotubes, diamond and diamond-like carbon, fullerenes, glassy carbon, graphite, graphene, graphene-oxide, porous carbons, pyrolytic carbon, and other sp2 and non-sp2 hybridized carbon systems. Carbon is the companion title to the open access journal Carbon Trends. Relevant application areas for carbon materials include biology and medicine, catalysis, electronic, optoelectronic, spintronic, high-frequency, and photonic devices, energy storage and conversion systems, environmental applications and water treatment, smart materials and systems, and structural and thermal applications.